Juyoun Janis Park, Yeri Alice Rim, Yeowon Sohn, Yoojun Nam, Ji Hyeon Ju
{"title":"Prospects of induced pluripotent stem cells in treating advancing Alzheimer's disease: A review.","authors":"Juyoun Janis Park, Yeri Alice Rim, Yeowon Sohn, Yoojun Nam, Ji Hyeon Ju","doi":"10.14670/HH-18-766","DOIUrl":null,"url":null,"abstract":"<p><p>The World Health Organization has identified Alzheimer's disease (AD), the leading cause of dementia globally, as a public health priority. However, the complex multifactorial pathology of AD means that its etiology remains incompletely understood. Despite being recognized a century ago, incomplete knowledge has hindered the development of effective treatments for AD. Recent scientific advancements, particularly in induced pluripotent stem cell (iPSC) technology, show great promise in elucidating the fundamental mechanisms of AD. iPSCs play a dual role in regenerating damaged cells for therapeutic purposes and creating disease models to understand AD pathology and aid in drug screening. Nevertheless, as an emerging field, iPSC technology requires further technological advancement to develop effective AD treatments in the future. Thus, this review summarizes recent advances in stem cell therapies, specifically iPSCs, aimed at understanding AD pathology and developing treatments.</p>","PeriodicalId":13164,"journal":{"name":"Histology and histopathology","volume":" ","pages":"157-170"},"PeriodicalIF":2.5000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Histology and histopathology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.14670/HH-18-766","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/21 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The World Health Organization has identified Alzheimer's disease (AD), the leading cause of dementia globally, as a public health priority. However, the complex multifactorial pathology of AD means that its etiology remains incompletely understood. Despite being recognized a century ago, incomplete knowledge has hindered the development of effective treatments for AD. Recent scientific advancements, particularly in induced pluripotent stem cell (iPSC) technology, show great promise in elucidating the fundamental mechanisms of AD. iPSCs play a dual role in regenerating damaged cells for therapeutic purposes and creating disease models to understand AD pathology and aid in drug screening. Nevertheless, as an emerging field, iPSC technology requires further technological advancement to develop effective AD treatments in the future. Thus, this review summarizes recent advances in stem cell therapies, specifically iPSCs, aimed at understanding AD pathology and developing treatments.
阿尔茨海默病（AD）是全球痴呆症的主要病因，世界卫生组织已将其列为公共卫生优先事项。然而，由于阿兹海默症的病因复杂且多因素，人们对其病因的了解仍不全面。尽管人们早在一个世纪前就认识到了这一点，但不完整的知识阻碍了有效治疗老年痴呆症的发展。最近的科学进步，特别是诱导多能干细胞（iPSC）技术的发展，为阐明AD的基本机制带来了巨大希望。iPSC具有双重作用，既能再生受损细胞用于治疗，又能创建疾病模型以了解AD的病理并帮助药物筛选。然而，作为一个新兴领域，iPSC 技术需要进一步的技术进步才能在未来开发出有效的 AD 治疗方法。因此，本综述总结了干细胞疗法，特别是iPSC的最新进展，旨在了解AD病理和开发治疗方法。
期刊介绍：
HISTOLOGY AND HISTOPATHOLOGY is a peer-reviewed international journal, the purpose of which is to publish original and review articles in all fields of the microscopical morphology, cell biology and tissue engineering; high quality is the overall consideration. Its format is the standard international size of 21 x 27.7 cm. One volume is published every year (more than 1,300 pages, approximately 90 original works and 40 reviews). Each volume consists of 12 numbers published monthly online. The printed version of the journal includes 4 books every year; each of them compiles 3 numbers previously published online.
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