Plant Flavonoids with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus (MRSA).

IF 4 2区医学 Q2 CHEMISTRY, MEDICINAL

ACS Infectious Diseases Pub Date : 2024-09-13 Epub Date: 2024-06-04 DOI:10.1021/acsinfecdis.4c00292

Shengnan Xu, Ayue Kang, Yue Tian, Xinhui Li, Shangshang Qin, Ruige Yang, Yong Guo

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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) has become a serious threat to human public health and global economic development, and there is an urgent need to develop new antimicrobial agents. Flavonoids are the largest group of plant secondary metabolites, and the anti-S. aureus and anti-MRSA activities of flavonoids have now been widely reported. The aim of this Review is to describe plant-derived flavonoid active ingredients and their effects and mechanisms of inhibitory activity against MRSA in order to provide insights for screening novel antimicrobial agents. Here, 85 plant-derived flavonoids (14 flavones, 21 flavonols, 26 flavanones, 9 isoflavones, 12 chalcones, and 3 other classes) with anti-MRSA activity are reviewed. Among these flavonoids, flavones and isoflavones generally showed the most significant anti-MRSA activity (MICs: 1-8 μg/mL). The results of the present Review display that most of the flavonoids with excellent anti-MRSA activity were derived from Morus alba L. and Paulownia tomentosa (Thunb.) Steud. The antibacterial mechanism of flavonoids against MRSA is mainly achieved by disruption of membrane structures, inhibition of efflux pumps, and inhibition of β-lactamases and bacterial virulence factors. We hope this Review can provide insights into the development of novel antimicrobials based on natural products for treating MRSA infections.

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具有抗耐甲氧西林金黄色葡萄球菌（MRSA）活性的植物类黄酮。

耐甲氧西林金黄色葡萄球菌（MRSA）已成为人类公共卫生和全球经济发展的严重威胁，因此迫切需要开发新的抗菌剂。黄酮类化合物是植物次生代谢产物中最大的一类，黄酮类化合物的抗金黄色葡萄球菌和抗 MRSA 活性现已被广泛报道。本综述旨在描述植物黄酮类活性成分及其对 MRSA 的抑制作用和机制，从而为筛选新型抗菌剂提供启示。本文综述了 85 种具有抗 MRSA 活性的植物黄酮类化合物（14 种黄酮、21 种黄酮醇、26 种黄烷酮、9 种异黄酮、12 种查耳酮和 3 种其他类别）。在这些黄酮类化合物中，黄酮和异黄酮一般具有最显著的抗 MRSA 活性（MICs：1-8 μg/mL）。本综述的结果表明，大多数具有卓越抗 MRSA 活性的黄酮类化合物来自白桑树（Morus alba L.）和泡桐（Paulownia tomentosa (Thunb.) Steud）。黄酮类化合物对MRSA的抗菌机制主要是通过破坏膜结构、抑制外排泵、抑制β-内酰胺酶和细菌毒力因子来实现的。我们希望这篇综述能为开发基于天然产品的新型抗菌药物治疗 MRSA 感染提供启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Infectious Diseases CHEMISTRY, MEDICINALINFECTIOUS DISEASES&nb-INFECTIOUS DISEASES

CiteScore

9.70

自引率

3.80%

发文量

213

期刊介绍： ACS Infectious Diseases will be the first journal to highlight chemistry and its role in this multidisciplinary and collaborative research area. The journal will cover a diverse array of topics including, but not limited to: * Discovery and development of new antimicrobial agents — identified through target- or phenotypic-based approaches as well as compounds that induce synergy with antimicrobials. * Characterization and validation of drug target or pathways — use of single target and genome-wide knockdown and knockouts, biochemical studies, structural biology, new technologies to facilitate characterization and prioritization of potential drug targets. * Mechanism of drug resistance — fundamental research that advances our understanding of resistance; strategies to prevent resistance. * Mechanisms of action — use of genetic, metabolomic, and activity- and affinity-based protein profiling to elucidate the mechanism of action of clinical and experimental antimicrobial agents. * Host-pathogen interactions — tools for studying host-pathogen interactions, cellular biochemistry of hosts and pathogens, and molecular interactions of pathogens with host microbiota. * Small molecule vaccine adjuvants for infectious disease. * Viral and bacterial biochemistry and molecular biology.