Thyroid hormones and stroke, the gap between clinical and experimental studies

IF 3.5 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2024-05-23 DOI:10.1016/j.brainresbull.2024.110983

Sakineh Shafia , Ashraf Khoramirad , Kobra Akhoundzadeh

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引用次数: 0

Abstract

Despite plenty of human studies on changes in thyroid hormones after stroke and some animal studies that assessed the effects of thyroid hormone administration on stroke, conclusive evidence for clinical application is lacking. This review aimed to determine the consistency of the results between clinical and preclinical studies. This article reviewed the PubMed, Embase, web of Knowledge, and Google Scholar databases up to June 2023 using the MeSH terms “stroke, cerebral ischemia, cerebral infarction, brain ischemia, brain infarction, triiodothyronine (T₃), tetraiodothyronine (T₄), thyroxine (T₄), and thyroid hormone". The results of clinical and preclinical studies related to T₃ substantially confirm each other. That is, in most human studies lower T₃ was associated with poor outcomes, and in experimental studies, T₃ administration also had therapeutic effects. However, the results of experimental studies related to T₄ could not support those of clinical studies. There seem to be some conflicts between experimental and human studies, especially regarding changes and effects of T₄ after stroke. The gap between experimental and clinical studies may lead to non-applicable results, wasting time and money, and unnecessary killing of animals.

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甲状腺激素与中风：临床与实验研究之间的差距

尽管有大量关于脑卒中后甲状腺激素变化的人体研究，以及一些评估甲状腺激素对脑卒中影响的动物研究，但仍缺乏临床应用的确凿证据。本综述旨在确定临床和临床前研究结果的一致性。本文以 "中风、脑缺血、脑梗塞、脑缺血、脑梗塞、三碘甲状腺原氨酸（T3）、四碘甲状腺原氨酸（T4）、甲状腺素（T4）和甲状腺激素 "为 MeSH 词，检索了截至 2023 年 6 月的 PubMed、Embase、web of Knowledge 和 Google Scholar 数据库。与 T3 有关的临床和临床前研究结果基本上相互印证。也就是说，在大多数人体研究中，较低的 T3 会导致不良后果，而在实验研究中，服用 T3 也有治疗效果。然而，与 T4 有关的实验研究结果却无法支持临床研究结果。实验研究与人体研究之间似乎存在一些冲突，尤其是在脑卒中后 T4 的变化和影响方面。实验研究与临床研究之间的差距可能会导致结果不适用、浪费时间和金钱，以及不必要地杀害动物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.