Association between maternal iron status and the risk of pre-eclampsia: a case-control study.

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS
Jin Jin, Ze Xu, Zhizuo Liu, Ludi Huang, Furong Liu, Min Liu, Yongye Sun
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Abstract

Background and objectives: This study aimed to assess the associations of maternal iron status and placental iron transport proteins expression with the risk of pre-eclampsia (PE) in Chinese pregnant women.

Methods and study design: A total of 94 subjects with PE and 112 healthy pregnant women were enrolled. Fasting blood samples were collected to detect maternal iron status. The placenta samples were collected at delivery to detect the mRNA and protein expression of divalent metal transporter 1 (DMT1) and ferroportin-1 (FPN1). Logistic analysis was used to explore the associations of maternal iron status with PE risk. The associations of placental iron transport proteins with maternal iron status were explored.

Results: After adjusting for covariates, dietary total iron, non-heme iron intake and serum hepcidin were negatively associated with PE, with adjusted ORs (95%CIs) were 0.40 (0.17, 0.91), 0.42 (0.18, 0.94) and 0.02 (0.002, 0.13) for the highest versus lowest tertile, respectively. For the highest tertile versus lowest tertile, serum iron (4.08 (1.58, 10.57)) and ferritin (5.61 (2.36, 13.31)) were positively associated with PE. The mRNA expressions and protein levels of DMT1 and FPN1 in placenta were up-regulated in the PE group (p < 0.05). The mRNA expressions of DMT1 and FPN1 in placenta showed a negative correlation with the serum hepcidin (r = -0.71, p < 0.001; r = -0.49, p < 0.05).

Conclusions: In conclusion, the maternal iron status were closely associated with PE risk, placental DMT1 and FPN1 were upregulated in PE which may be a promising target for the prevention of PE.

产妇铁质状况与先兆子痫风险之间的关系:一项病例对照研究。
背景和目的:本研究旨在评估中国孕妇母体铁状态和胎盘铁转运蛋白表达与子痫前期(PE)风险的关系:本研究旨在评估中国孕妇母体铁状态和胎盘铁转运蛋白表达与子痫前期(PE)风险的相关性:方法和研究设计:共招募了94名子痫前期孕妇和112名健康孕妇。采集空腹血样以检测母体铁状况。采集分娩时的胎盘样本,检测二价金属转运体 1(DMT1)和铁蛋白-1(FPN1)的 mRNA 和蛋白表达。采用逻辑分析法探讨了母体铁状况与 PE 风险的关系。研究还探讨了胎盘铁转运蛋白与母体铁状况的关系:调整协变量后,膳食总铁、非血红素铁摄入量和血清血红素与 PE 呈负相关,调整后的 ORs(95%CIs)分别为 0.40(0.17,0.91)、0.42(0.18,0.94)和 0.02(0.002,0.13)。血清铁(4.08 (1.58, 10.57))和铁蛋白(5.61 (2.36, 13.31))与 PE 呈正相关。PE 组胎盘中 DMT1 和 FPN1 的 mRNA 表达和蛋白水平均上调(P < 0.05)。胎盘中 DMT1 和 FPN1 的 mRNA 表达与血清血红素呈负相关(r = -0.71,p < 0.001;r = -0.49,p < 0.05):总之,母体铁状况与PE风险密切相关,胎盘DMT1和FPN1在PE中上调,这可能是预防PE的一个有前景的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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