Cytophagic histiocytic panniculitis leading to a diagnosis of acute myeloid leukemia with monocytic differentiation: A case report and literature review

IF 1.6 4区 医学 Q3 DERMATOLOGY
Taylor E. Arnoff, Fatima N. Mirza, Sara Yumeen, Shaza Ben Khadra, Dean David George, Leslie Robinson-Bostom
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引用次数: 0

Abstract

Cytophagic histiocytic panniculitis (CHP) is associated with a number of systemic conditions and is characterized by the presence of benign phagocytic histiocytes (“bean bag cells”), including phagocytosed erythrocytes, leukocytes, and platelets. We describe a case of a 72-year-old female who presented with a papular eruption that clinically mimicked pityriasis lichenoides et varioliformis acuta (PLEVA). Given that her skin biopsy had multiple features concerning PLEVA, this diagnosis was classified as a superficial pityriasis lichenoides-like variant of CHP. The histopathologic presence of cytophagic histiocytosis prompted workup for a systemic malignancy, leading to a diagnosis of underlying acute monocytic leukemia of myeloid lineage.

嗜细胞组织细胞性泛酸炎导致诊断为单核细胞分化的急性髓性白血病:病例报告与文献综述。
噬细胞组织细胞性盘状丘疹(CHP)与多种全身性疾病有关,其特征是存在良性吞噬性组织细胞("豆袋细胞"),包括吞噬红细胞、白细胞和血小板。我们描述了一例 72 岁女性的病例,她出现了丘疹性荨麻疹,临床上类似于 "脓疱性苔藓和变性苔藓"(PLEVA)。鉴于她的皮肤活检结果具有与 PLEVA 相关的多个特征,该诊断被归类为 CHP 的浅表怜悯苔癣样变异。组织病理学上出现的嗜细胞组织细胞增生症促使患者进行全身恶性肿瘤检查,最终诊断为潜在的髓系急性单核细胞白血病。
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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
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