Implementation of a pharmacovigilance system to detect adverse events and improve medication appropriateness in a hospital in Indonesia

IF 0.5 Q4 EDUCATION, SCIENTIFIC DISCIPLINES

Pharmacy Education Pub Date : 2024-05-01 DOI:10.46542/pe.2024.243.711

D. Atmaja, Yulistiani Yulistiani, S. Suharjono, E. Zairina

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引用次数: 0

Abstract

Background: The growing elderly population has led to an increased occurrence of adverse drug reactions (ADRs) due to the various drugs they are prescribed, posing the problem of potential drug interactions. The application of causality instruments combined with trigger tools and the competency of healthcare professionals has yielded better results in detecting ADRs. Objective: To evaluate the implementation of a pharmacovigilance system to detect ADRs, potentially inappropriate medications, and potential prescription omissions. Methods: An observational, descriptive, prospective study was conducted over six weeks at one of the largest hospitals in Indonesia. The pharmacist and the physicians collaborated in reviewing patient medication records using the pharmacovigilance system. Results: The study enrolled 144 patients. The 163 positive triggers identified helped detect 28 Adverse Drug Events (ADEs) caused by at least one high-alert medication. These ADEs occurred in 25 patients. Additionally, 62 potentially inappropriate medications and 41 potential prescription omissions were detected. Conclusion: The pharmacovigilance system could reduce the frequency of ADEs caused by medications used in elderly patients.

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印度尼西亚一家医院实施药物警戒系统以检测不良事件并提高用药适当性

背景：随着老年人口的不断增加，他们服用的各种药物导致的药物不良反应（ADRs）也随之增加，从而引发了潜在的药物相互作用问题。将因果关系工具与触发工具相结合，并提高医护人员的能力，在检测 ADR 方面取得了更好的效果：评估药物警戒系统的实施情况，以发现药物不良反应、潜在的用药不当和潜在的处方遗漏：在印度尼西亚最大的医院之一进行了一项为期六周的观察性、描述性、前瞻性研究。药剂师和医生合作使用药物警戒系统查看患者用药记录：结果：研究共招募了 144 名患者。在确定的 163 个阳性触发因素中，发现了 28 例由至少一种高警戒药物引起的药物不良事件 (ADE)。这些不良反应发生在 25 名患者身上。此外，还发现了 62 种潜在的不适当药物和 41 种潜在的处方遗漏：药物警戒系统可降低老年患者用药导致的 ADE 发生率。

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来源期刊

Pharmacy Education EDUCATION, SCIENTIFIC DISCIPLINES-

CiteScore

0.80

自引率

20.00%

发文量

174

期刊介绍： Pharmacy Education journal provides a research, development and evaluation forum for communication between academic teachers, researchers and practitioners in professional and pharmacy education, with an emphasis on new and established teaching and learning methods, new curriculum and syllabus directions, educational outcomes, guidance on structuring courses and assessing achievement, and workforce development. It is a peer-reviewed online open access platform for the dissemination of new ideas in professional pharmacy education and workforce development. Pharmacy Education supports Open Access (OA): free, unrestricted online access to research outputs. Readers are able to access the Journal and individual published articles for free - there are no subscription fees or ''pay per view'' charges. Authors wishing to publish their work in Pharmacy Education do so without incurring any financial costs.