Feasible mechanisms and therapeutic potential of food probiotics to mitigate diabetes-associated cancers: A comprehensive review and in silico validation

IF 7.4 Q1 FOOD SCIENCE & TECHNOLOGY
Food frontiers Pub Date : 2024-05-01 DOI:10.1002/fft2.406
Annadurai Vinothkanna, Xiang Shi-Liang, Durairaj Karthick Rajan, Ragothaman Prathiviraj, Soundarapandian Sekar, Shubing Zhang, Bo Wang, Zhu Liu, Ai-Qun Jia
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Abstract

People with diabetes mellitus (DM) and hyperglycemia are linked with cancer risk. Diabetes and cancer have been corroborated by high morbidity and mortality rates. Studies revealed that elevated levels of insulin secretions trigger insulin-like growth factor 1 (IGF-1) production. Moreover, IGF-1 is a key regulator involved in promoting cancer cell progression and is linked with DM. Cancer drug resistance and ototoxic effects can adversely affect the health and lifespan of an individual. However, naturally derived bioactive compounds are gaining attention for their nontoxic properties and specific behavior. Likewise, probiotics have also been regarded as safe and successful alternatives to treat DM-linked cancers. The present review aims to highlight the therapeutic potential and feasible functions of probiotics to mitigate or inhibit DM-associated cancers. Meanwhile, the intracellular signaling cascades involved in promoting DM-linked cancer are enumerated for future prospective research. However, metabolomics interactions and protein–protein interactions are to be discussed for deeper insights into affirmative principles in diabetic-linked cancers. Drug discovery and innovative preclinical evaluation need further adjuvant and immune-enhancement therapies. Furthermore, the results of the in silico assessment could provide scientific excellence of IGF-1 in diabetes and cancer. Overall, this review summarizes the mechanistic insights and therapeutic targets for diabetes-associated cancer.

Abstract Image

食物益生菌缓解糖尿病相关癌症的可行机制和治疗潜力:全面综述与硅学验证
糖尿病(DM)患者和高血糖与癌症风险有关。高发病率和高死亡率证实了糖尿病与癌症的关系。研究发现,胰岛素分泌水平的升高会引发胰岛素样生长因子 1(IGF-1)的产生。此外,IGF-1 是促进癌细胞进展的关键调节因子,与糖尿病有关。癌症耐药性和耳毒性效应会对个人的健康和寿命产生不利影响。然而,天然提取的生物活性化合物因其无毒特性和特殊行为而日益受到关注。同样,益生菌也被认为是治疗与 DM 相关癌症的安全、成功的替代品。本综述旨在强调益生菌在缓解或抑制 DM 相关癌症方面的治疗潜力和可行功能。同时,还列举了参与促进DM相关癌症的细胞内信号级联,以供未来的前瞻性研究之用。然而,为了更深入地了解糖尿病相关癌症的肯定性原理,代谢组学相互作用和蛋白质与蛋白质之间的相互作用也有待讨论。药物发现和创新性临床前评估需要进一步的辅助疗法和免疫增强疗法。此外,硅学评估的结果可为 IGF-1 在糖尿病和癌症中的应用提供科学依据。总之,本综述总结了糖尿病相关癌症的机理认识和治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
10.50
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0.00%
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审稿时长
10 weeks
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