Economic Income And Survival In Patients Affected By Glioblastoma: A Systematic Review And Meta-Analysis

IF 2.4 Q2 CLINICAL NEUROLOGY

Neuro-oncology practice Pub Date : 2024-05-11 DOI:10.1093/nop/npae045

V. Di Nunno, L. Gatto, Marta Aprile, S. Bartolini, A. Tosoni, Enrico Franceschi

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Abstract

Within socio-economic variables, economic income has been associated with the prognosis of patients with glioblastoma. However, studies investigating this issue provided conflicting results We carried out a systematic review and meta-analysis of studies investigating the correlation between economic income and survival in patients with glioblastoma. The inverse variance technique for HR assessment has been employed reporting the random effect model. We included 12 studies for a total of 143303 GBM patients (67463 with high economic income, and 25679 with low economic income). In the overall analysis, lower economic income resulted in poorer survival (pooled HR 1.09, 95%CI, 1.02-1.17, I2=64%). Variables like the type of Health Care System (public, private, or mixed) and the time in which patients have been treated (pre or post-EORTC-NCIC trial 22981/26981, CE.3 protocol advent) did not modify survival on pooled analysis. Economic conditions and income influence the prognosis of patients with glioblastoma. A better understanding of the modifiable barriers leading to treatment disparities in more disadvantaged patients is warranted to make equal oncological care.

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胶质母细胞瘤患者的经济收入与生存期：系统回顾与元分析

在社会经济变量中，经济收入与胶质母细胞瘤患者的预后有关。我们对调查胶质母细胞瘤患者经济收入与生存之间相关性的研究进行了系统回顾和荟萃分析。我们采用了反方差技术进行HR评估，并报告了随机效应模型。我们共纳入了 12 项研究，共计 143303 名胶质母细胞瘤患者（67463 名经济收入高，25679 名经济收入低）。在总体分析中，经济收入越低，生存率越低（汇总 HR 1.09，95%CI，1.02-1.17，I2=64%）。医疗保健系统的类型（公立、私立或混合）和患者接受治疗的时间（EORTC-NCIC 22981/26981 试验前或试验后，CE.3 方案来临前或试验后）等变量在汇总分析中不会改变生存率。经济条件和收入会影响胶质母细胞瘤患者的预后。为了实现平等的肿瘤治疗，有必要更好地了解导致弱势患者治疗差异的可改变的障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuro-oncology practice CLINICAL NEUROLOGY-

CiteScore

5.30

自引率

11.10%

发文量

期刊介绍： Neuro-Oncology Practice focuses on the clinical aspects of the subspecialty for practicing clinicians and healthcare specialists from a variety of disciplines including physicians, nurses, physical/occupational therapists, neuropsychologists, and palliative care specialists, who have focused their careers on clinical patient care and who want to apply the latest treatment advances to their practice. These include: Applying new trial results to improve standards of patient care Translating scientific advances such as tumor molecular profiling and advanced imaging into clinical treatment decision making and personalized brain tumor therapies Raising awareness of basic, translational and clinical research in areas of symptom management, survivorship, neurocognitive function, end of life issues and caregiving