Formulation of self-nanoemulsifying drug delivery system (SNEDDS) of combined 70% ethanolic of Begonia medicinalis herbs and Moringa oleifera leaves

IF 0.5 Q4 EDUCATION, SCIENTIFIC DISCIPLINES

Pharmacy Education Pub Date : 2024-05-13 DOI:10.46542/pe.2024.243.304309

Nur Asita, Muhammad Sulaiman Zubair, Y. Syukri, Evi Sulastri

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引用次数: 0

Abstract

Background: Benalu batu (Begonia medicinalis) and kelor leaves (Moringa oleifera) are empirically used as alternative therapies by people in Central Sulawesi to maintain their health. Our previous research showed that the combination of these two plant extracts possessed an immunomodulatory activity. Self-Nanoemulsifying Drug Delivery System (SNEDDS) formulation was performed to improve the extract's bioavailability, solubility and stability. Objective: This study aims to formulate and characterise SNEDDS preparations of combined ethanolic extract of B. medicinalis herbs and M. oleifera leaves and further test its stability. Method: SNEDDS formulation was started by screening for proper oil, surfactant, and co-surfactant. The formula was then optimised using a ternary phase diagram and characterisation. The stability test was performed using centrifugation, heating-cooling, and freeze-thaw cycles. Results: The optimal SNEDDS formula consists of isopropyl myristate (10%), tween 80 (50%) and propylene glycol (40%). The characterisation values obtained were: Transmittance value 83.785 ± 0.275%, particle size 18.666 ± 0.208 nm, polydispersity index 0.664 ± 0.0085, and zeta potential -39.20 ± 0.2 mV. The formula was stable during three stability evaluation tests. Conclusion: The optimal formula met the SNEDDS characteristics requirements and showed good stability.

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海棠药材和油辣木叶 70%乙醇的自纳米乳化给药系统（SNEDDS）配方

背景：中苏拉威西岛的人们根据经验使用贝纳鲁巴图（Begonia medicinalis）和凯洛叶（Moringa oleifera）作为替代疗法来保持健康。我们之前的研究表明，这两种植物提取物的组合具有免疫调节活性。为了提高提取物的生物利用度、溶解度和稳定性，我们采用了自纳米乳化给药系统（SNEDDS）配方：本研究旨在配制 B. medicinalis 草本和 M. oleifera 叶片乙醇提取物的 SNEDDS 制剂并确定其特性，并进一步测试其稳定性：通过筛选合适的油、表面活性剂和辅助表面活性剂，开始配制 SNEDDS。然后使用三元相图和表征法对配方进行优化。通过离心、加热-冷却和冻融循环进行稳定性测试：最佳 SNEDDS 配方由肉豆蔻酸异丙酯（10%）、吐温 80（50%）和丙二醇（40%）组成。获得的特性值如下透光率为 83.785 ± 0.275%，粒径为 18.666 ± 0.208 nm，多分散指数为 0.664 ± 0.0085，Zeta 电位为 -39.20 ± 0.2 mV。该配方在三次稳定性评估测试中表现稳定：结论：最佳配方符合 SNEDDS 的特性要求，并表现出良好的稳定性。

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来源期刊

Pharmacy Education EDUCATION, SCIENTIFIC DISCIPLINES-

CiteScore

0.80

自引率

20.00%

发文量

174

期刊介绍： Pharmacy Education journal provides a research, development and evaluation forum for communication between academic teachers, researchers and practitioners in professional and pharmacy education, with an emphasis on new and established teaching and learning methods, new curriculum and syllabus directions, educational outcomes, guidance on structuring courses and assessing achievement, and workforce development. It is a peer-reviewed online open access platform for the dissemination of new ideas in professional pharmacy education and workforce development. Pharmacy Education supports Open Access (OA): free, unrestricted online access to research outputs. Readers are able to access the Journal and individual published articles for free - there are no subscription fees or ''pay per view'' charges. Authors wishing to publish their work in Pharmacy Education do so without incurring any financial costs.