Commiphora gileadenesis Extracts Reduce Blood Glucose Levels, HbA1c, Lipid Profile, and CD4+ and CD8+ Subsets in Type 1 Diabetic Mice

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Natural Product Communications Pub Date : 2024-05-10 DOI:10.1177/1934578x241250249

Ayman Saeed Alhazmi, Abdullah Aldairi, Abdulelah Aljuaid, Ahmad Alghamdi, Mamdouh Allahyani

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Abstract

Diabetes mellitus is a major health problem that affects the general population. Commiphora gileadensis ( C gileadensis) is a small tree that grows in the Middle East. Objective: This study explored the effect of C gileadensis on blood glucose levels, lipid profile, and T lymphocytes subsets using flow cytometry. Methodology: Forty male mice were classified into four groups: negative control; diabetic nontreated; and two groups of diabetic mice treated with C gileadensis sap and acetone extract. The blood glucose levels, lipid profile, and HbA1c were estimated for each mouse in the four groups. Moreover, total lymphocytes, CD3+, CD4+, CD8+, and CD25+ subsets were estimated for all groups. Results: The blood glucose levels, triglyceride, total cholesterol, and HbA1c were significantly reduced in mice treated with C gileadensis sap and acetone extract compared with the diabetic group. Total lymphocyte and CD3+ were reduced in diabetic mice treated with C gileadensis sap and acetone extract compared with the untreated diabetic group ( P < .05). In addition, CD4+ and CD8+ subsets were decreased in the same groups compared with the untreated one ( P < .05). CD4+ CD25+ cells were decreased in all diabetic groups compared with the control group ( P < .05). CD8+ CD25+ were increased in diabetic groups treated with C gileadensis sap and acetone extract compared with the untreated diabetic group ( P < .05). Conclusion: The present study concludes that C gileadensis sap and acetone extracts reduce the blood glucose, HbA1c, and lipid profile in diabetic mice. Moreover, this herb has anti-inflammatory properties that may help in the normalization of glycemic index and prevent T1DM progression.

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商陆提取物可降低 1 型糖尿病小鼠的血糖水平、HbA1c、血脂组合以及 CD4+ 和 CD8+ 子集

糖尿病是影响大众健康的一个主要问题。吉利莲（Commiphora gileadensis）是一种生长在中东地区的小乔木。研究目的本研究使用流式细胞术探讨了茜草对血糖水平、血脂状况和 T 淋巴细胞亚群的影响。研究方法：将 40 只雄性小鼠分为四组：阴性对照组；未接受糖尿病治疗组；接受 C gileadensis 树液和丙酮提取物治疗的两组糖尿病小鼠。对四组中每只小鼠的血糖水平、血脂状况和 HbA1c 进行估计。此外，还对所有组的总淋巴细胞、CD3+、CD4+、CD8+和CD25+亚群进行了估计。结果与糖尿病组相比，用吉利莲树液和丙酮提取物治疗的小鼠的血糖水平、甘油三酯、总胆固醇和 HbA1c 均显著降低。与未治疗的糖尿病组相比，使用吉利丁树液和丙酮提取物治疗的糖尿病小鼠的总淋巴细胞和 CD3+ 减少（P <.05）。此外，与未处理组相比，CD4+和CD8+亚群也有所减少（P < .05）。与对照组相比，所有糖尿病组的 CD4+ CD25+ 细胞都减少了（P < .05）。与未经处理的糖尿病组相比，经 C gileadensis 树液和丙酮提取物处理的糖尿病组 CD8+ CD25+ 细胞增多 ( P < .05)。结论：本研究得出结论，C gileadensis 树液和丙酮提取物可降低糖尿病小鼠的血糖、HbA1c 和血脂。此外，这种草药还具有抗炎特性，可能有助于使血糖指数正常化并防止 T1DM 的恶化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Communications 工程技术-食品科技

CiteScore

3.10

自引率

11.10%

发文量

254

审稿时长

2.7 months

期刊介绍： Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products.