The roles of PD-L1 in the various stages of tumor metastasis.

IF 7.7 2区 医学 Q1 ONCOLOGY
Cancer and Metastasis Reviews Pub Date : 2024-12-01 Epub Date: 2024-05-11 DOI:10.1007/s10555-024-10189-4
Yinjun He, Ming Zhu, Xuan Lai, Honghe Zhang, Weiqin Jiang
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引用次数: 0

Abstract

The interaction between tumor programmed death ligand 1 (PD-L1) and T-cell programmed cell death 1 (PD-1) has long been acknowledged as a mechanism for evading immune surveillance. Recent studies, however, have unveiled a more nuanced role of tumor-intrinsic PD-L1 in reprograming tumoral phenotypes. Preclinical models emphasize the synchronized effects of both intracellular and extracellular PD-L1 in promoting metastasis, with intricate interactions with the immune system. This review aims to summarize recent findings to elucidate the spatiotemporal heterogeneity of PD-L1 expression and the pro-metastatic roles of PD-L1 in the entire process of tumor metastasis. For example, PD-L1 regulates the epithelial-to-mesenchymal transition (EMT) process, facilitates the survival of circulating tumor cells, and induces the formation of immunosuppressive environments at pre-metastatic niches and metastatic sites. And the complexed and dynamic regulation process of PD-L1 for tumor metastasis is related to the spatiotemporal heterogeneity of PD-L1 expression and functions from tumor primary sites to various metastatic sites. This review extends the current understandings for the roles of PD-L1 in mediating tumor metastasis and provides new insights into therapeutic decisions in clinical practice.

Abstract Image

PD-L1 在肿瘤转移各阶段中的作用。
肿瘤程序性死亡配体1(PD-L1)与T细胞程序性细胞死亡1(PD-1)之间的相互作用一直被认为是逃避免疫监视的一种机制。然而,最近的研究揭示了肿瘤内源性 PD-L1 在重编程肿瘤表型中更微妙的作用。临床前模型强调了细胞内和细胞外 PD-L1 在促进转移方面的同步作用,以及与免疫系统之间错综复杂的相互作用。本综述旨在总结最近的研究结果,以阐明 PD-L1 表达的时空异质性以及 PD-L1 在肿瘤转移全过程中的促转移作用。例如,PD-L1调控上皮细胞向间质转化(EMT)过程,促进循环肿瘤细胞的存活,诱导转移前壁龛和转移部位形成免疫抑制环境。而 PD-L1 对肿瘤转移的复杂动态调控过程与 PD-L1 从肿瘤原发部位到不同转移部位的表达和功能的时空异质性有关。本综述扩展了目前对 PD-L1 在介导肿瘤转移中作用的认识,并为临床实践中的治疗决策提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
17.00
自引率
0.00%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms.The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments. A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.
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