Wenyan Zhang, Hong-Shuo Sun, Xiaoying Wang, Aaron S Dumont, Qiang Liu
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引用次数: 0
Abstract
Aging may lead to low-level chronic inflammation that increases the susceptibility to age-related conditions, including memory impairment and progressive loss of brain volume. As brain health is essential to promoting healthspan and lifespan, it is vital to understand age-related changes in the immune system and central nervous system (CNS) that drive normal brain aging. However, the relative importance, mechanistic interrelationships, and hierarchical order of such changes and their impact on normal brain aging remain to be clarified. Here, we synthesize accumulating evidence that age-related DNA damage and cellular senescence in the immune system and CNS contribute to the escalation of neuroinflammation and cognitive decline during normal brain aging. Targeting cellular senescence and immune modulation may provide a logical rationale for developing new treatment options to restore immune homeostasis and counteract age-related brain dysfunction and diseases.
衰老可能会导致低水平的慢性炎症，从而增加对与年龄有关的疾病的易感性，包括记忆损伤和脑容量的逐渐丧失。由于大脑健康对促进健康和寿命至关重要，因此了解免疫系统和中枢神经系统（CNS）中与年龄相关的、驱动大脑正常衰老的变化至关重要。然而，这些变化的相对重要性、机理上的相互关系、层次顺序及其对正常脑衰老的影响仍有待澄清。在这里，我们综合了越来越多的证据，证明与年龄相关的 DNA 损伤以及免疫系统和中枢神经系统中的细胞衰老是正常脑衰老过程中神经炎症升级和认知能力下降的原因。以细胞衰老和免疫调节为靶点，可以为开发新的治疗方案提供合理的依据，从而恢复免疫平衡，对抗与年龄相关的脑功能障碍和疾病。
期刊介绍：
For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.
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