Efficacy and Safety of Therapeutic Plasma Exchange in Children with Neuroimmunological Disorders: A Limited Unicentral Study.

IF 0.8 Q4 CLINICAL NEUROLOGY

Iranian Journal of Child Neurology Pub Date : 2024-01-01 Epub Date: 2024-03-12 DOI:10.22037/ijcn.v18i1.40139

Ali Nikkhah, Mohammad Mahdi Nasehi, Nader Momtazmanesh, Kourosh Etemad, Somayeh Hajatnia

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引用次数: 0

Abstract

Objectives: Therapeutic plasma exchange (TPE) is a plasmapheresis procedure whose Safety data for pediatric neuro-immunological disorders (PNID) is confined. The present research documents TPE's safety and feasibility data in these conditions.

Materials & methods: The current study involved six distinct groups of patients with PNID undergoing TPE: neuromyelitis optic spectrum disorder (NMOSD), autoimmune encephalitis (AIE), acute disseminated encephalomyelitis (ADEM), multiple sclerosis (MS), Guillain-Barre syndrome (GBS), and optic neuritis (ON). This study documented complications related to each TPE process. In addition, TPE's efficacy was studied in these patients.

Results: The present study recorded adverse effects in 18 patients with PNID that received 121 TPE cycles: five cycles (4.13%) in MS, three (2.48%) in AIE subgroup, one (0.82%) in ADEM, and two (1.65%) in GBS. No severe complications were observed among the patients.

Conclusion: Patients with PNID tolerated therapeutic plasma exchange, which was a safe process.

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治疗性血浆置换对神经免疫紊乱儿童的有效性和安全性：一项有限的单中心研究

目的：治疗性血浆置换（TPE）是一种血浆置换程序，但其用于小儿神经免疫疾病（PNID）的安全性数据有限。本研究记录了 TPE 在这些病症中的安全性和可行性数据：本研究涉及六组接受 TPE 治疗的 PNID 患者：神经脊髓炎视谱系障碍 (NMOSD)、自身免疫性脑炎 (AIE)、急性播散性脑脊髓炎 (ADEM)、多发性硬化症 (MS)、格林-巴利综合征 (GBS) 和视神经炎 (ON)。这项研究记录了与每个 TPE 过程相关的并发症。此外，还研究了 TPE 对这些患者的疗效：本研究记录了接受 121 个 TPE 周期的 18 名 PNID 患者的不良反应：MS 患者 5 个周期（4.13%），AIE 亚组 3 个周期（2.48%），ADEM 患者 1 个周期（0.82%），GBS 患者 2 个周期（1.65%）。患者中未发现严重并发症：结论：PNID 患者能够耐受治疗性血浆置换，这是一个安全的过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Child Neurology CLINICAL NEUROLOGY-

CiteScore

1.40

自引率

0.00%

发文量