The effect of cognitive decline on the medication adherence in patients with type II diabetes mellitus

IF 0.5 Q4 EDUCATION, SCIENTIFIC DISCIPLINES

Pharmacy Education Pub Date : 2024-04-01 DOI:10.46542/pe.2024.242.163171

Indana Ayu Soraya, Rani Sauriasari, Pukovisa Prawirohardjo, H. W. Risni

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Abstract

Background: Type II Diabetes Mellitus (T2DM) is a risk factor for decreased cognitive function that is rarely recognised by patients, apart from age and other factors. Objective: This study aims to assess the effect of decreased cognitive function on medication adherence in T2DM patients. Method: This study used a cross-sectional design conducted at the Pasar Minggu Community Health Center, Jakarta, Indonesia. Cognitive function was assessed using the validated Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina) questionnaire. Results: One hundred twenty-seven T2DM patients (75.6% female) with a mean age of 58.69 years were recruited. The proportion of T2DM patients with decreased cognitive function was quite high, namely 61%. The proportion of non-adherent patients in the group with decreased cognitive function (70.6%) was greater than in the normal group (29.4%). Decreased cognitive function significantly affected non-adherence in taking medication with aOR 3.744 (95% CI 1.485–9.442), p = 0.005, after controlling for age, education level, HbA1c value, and comorbid dyslipidemia. Conclusion: Patients with decreased cognitive function are 3.7 times more likely to be non-compliant with medication, regardless of age, education level, HbA1c value, and dyslipidemia. Special management is needed for T2DM patients with decreased cognitive function, such as caregiver assistance, education by pharmacists, and simpler drug regimes.

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认知能力下降对 II 型糖尿病患者坚持服药的影响

背景：II 型糖尿病（T2DM）是导致认知功能下降的一个风险因素，除了年龄等因素外，患者很少意识到这一点：II型糖尿病（T2DM）是导致认知功能下降的一个危险因素，除了年龄和其他因素外，患者很少认识到这一点：本研究旨在评估认知功能下降对 T2DM 患者服药依从性的影响：本研究采用横断面设计，在印度尼西亚雅加达 Pasar Minggu 社区健康中心进行。认知功能采用经过验证的印尼版蒙特利尔认知评估（MoCA-Ina）问卷进行评估：共招募了 127 名 T2DM 患者（75.6% 为女性），平均年龄为 58.69 岁。认知功能下降的 T2DM 患者比例相当高，达到 61%。认知功能减退组未坚持服药的患者比例（70.6%）高于正常组（29.4%）。在控制了年龄、教育水平、HbA1c 值和合并血脂异常等因素后，认知功能减退对不坚持服药有明显影响，其 aOR 为 3.744 (95% CI 1.485-9.442)，p = 0.005：结论：无论年龄、教育程度、HbA1c 值和血脂异常与否，认知功能下降的患者不按时服药的几率是正常人的 3.7 倍。认知功能减退的 T2DM 患者需要特殊管理，如护理人员的协助、药剂师的教育和更简单的用药方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacy Education EDUCATION, SCIENTIFIC DISCIPLINES-

CiteScore

0.80

自引率

20.00%

发文量

174

期刊介绍： Pharmacy Education journal provides a research, development and evaluation forum for communication between academic teachers, researchers and practitioners in professional and pharmacy education, with an emphasis on new and established teaching and learning methods, new curriculum and syllabus directions, educational outcomes, guidance on structuring courses and assessing achievement, and workforce development. It is a peer-reviewed online open access platform for the dissemination of new ideas in professional pharmacy education and workforce development. Pharmacy Education supports Open Access (OA): free, unrestricted online access to research outputs. Readers are able to access the Journal and individual published articles for free - there are no subscription fees or ''pay per view'' charges. Authors wishing to publish their work in Pharmacy Education do so without incurring any financial costs.