Soybean meal peptide Gly-Thr-Tyr-Trp could protect mice from acute alcoholic liver damage: A study of protein-protein interaction and proteomic analysis

IF 9.8 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry Pub Date : 2024-04-15 DOI:10.1016/j.foodchem.2024.139337

Siwen Lyu, Zhuanzhang Cai, Qi Yang, Jingbo Liu, Yiding Yu, Fengguang Pan, Ting Zhang

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Abstract

Alcoholic liver disease (ALD) is a serious health threat. Soybean meal peptide (SMP) supplementation may protect against this damage; however, the potential mechanism underlying the specific sequence of SMPs is unclear. Protein-protein interaction and proteomic analyses are effective methods for studying functional ingredients in diseases. This study aimed to investigate the potential mechanism of action of the peptide Gly-Thr-Tyr-Trp (GTYW) on ALD using protein-protein interaction and proteomic analyses. These results demonstrate that GTYW influenced the targets of glutathione metabolism (glutathione-disulfide reductase, glutathione S-transferase pi 1, and glutathione S-transferase mu 2). It also regulated the expression of targets related to energy metabolism and amino acid conversion (trypsin-2, cysteine dioxygenase type-1, and F6SJM7). Amino acid and lipid metabolisms were identified based on Gene Ontology annotation. These results indicate that GTYW might affect alcohol-related liver disease signaling pathways. This study provides evidence of the protective and nutritional benefits of SMPs in ALD treatment.

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豆粕肽 Gly-Thr-Tyr-Trp 可保护小鼠免受急性酒精性肝损伤：蛋白质相互作用和蛋白质组分析研究

酒精性肝病（ALD）是一种严重威胁健康的疾病。补充大豆粉肽（SMP）可防止这种损害；然而，SMP 特定序列的潜在机制尚不清楚。蛋白质-蛋白质相互作用和蛋白质组分析是研究疾病中功能成分的有效方法。本研究旨在通过蛋白质-蛋白质相互作用和蛋白质组分析，研究多肽 Gly-Thr-Tyr-Trp (GTYW) 对 ALD 的潜在作用机制。这些结果表明，GTYW 会影响谷胱甘肽代谢的靶标（谷胱甘肽-二硫化物还原酶、谷胱甘肽 S 转移酶 pi 1 和谷胱甘肽 S 转移酶 mu 2）。它还能调节与能量代谢和氨基酸转化有关的靶标（胰蛋白酶-2、半胱氨酸二氧酶-1 型和 F6SJM7）的表达。根据基因本体注释确定了氨基酸和脂质代谢。这些结果表明，GTYW 可能会影响酒精相关肝病的信号通路。这项研究为SMPs在ALD治疗中的保护和营养益处提供了证据。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.