A randomized open-label, observational study of the novel ketone ester, bis octanoyl (R)-1,3-butanediol, and its acute effect on ß-hydroxybutyrate and glucose concentrations in healthy older adults

Elizabeth B. Stephens, Chatura Senadheera, Stephanie Roa-Diaz, Sawyer Peralta, Laura Alexander, Wendie Silverman-Martin, Michi Yukawa, Jenifer Morris, James B. Johnson, John C. Newman, Brianna J. Stubbs
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Abstract

Bis-octanoyl (R)-1,3-butanediol (BO-BD) is a novel ketone ester (KE) ingredient which increases blood beta-hydroxybutyrate (BHB) concentrations rapidly after ingestion. KE is hypothesized to have beneficial metabolic effects on health and performance, especially in older adults. Whilst many studies have investigated the ketogenic effect of KE in young adults, they have not been studied in an exclusively older adult population, for whom age-related differences in body composition and metabolism may alter the effects. This randomized, observational, open-label study in healthy older adults (n = 30, 50% male, age = 76.5 years, BMI = 25.2 kg/m2) aimed to elucidate acute tolerance, blood BHB and blood glucose concentrations for 4 hours following consumption of either 12.5 or 25 g of BO-BD formulated firstly as a ready-to-drink beverage (n = 30), then as a re-constituted powder (n = 21), taken with a standard meal. Both serving sizes and formulations of BO-BD were well tolerated, and increased blood BHB, inducing nutritional ketosis (≥ 0.5mM) that lasted until the end of the study. Ketosis was dose responsive; peak BHB concentration (Cmax) and incremental area under the curve (iAUC) were significantly greater with 25 g compared to 12.5 g of BO-BD in both formulations. There were no significant differences in Cmax or iAUC between formulations. Blood glucose increased in all conditions following the meal; there were no consistent significant differences in glucose response between conditions. These results demonstrate that both powder and beverage formulations of the novel KE, BO-BD, induce ketosis in healthy older adults, facilitating future research on functional effects of this ingredient in aging.
关于新型酮酯双辛酰(R)-1,3-丁二醇及其对健康老年人体内ß-羟丁酸和葡萄糖浓度的急性影响的随机开放标签观察研究
双辛酰(R)-1,3-丁二醇(BO-BD)是一种新型酮酯(KE)成分,摄入后能迅速增加血液中的β-羟丁酸(BHB)浓度。据推测,KE 对健康和工作表现具有有益的新陈代谢作用,尤其是对老年人。虽然许多研究都对 KE 在年轻人中的生酮效应进行了调查,但还没有专门针对老年人群进行过研究,因为与年龄有关的身体成分和新陈代谢差异可能会改变其效应。这项针对健康老年人(n = 30,50% 为男性,年龄 = 76.5 岁,体重指数 = 25.2 kg/m2)的随机、观察性、开放标签研究旨在阐明在食用 12.5 克或 25 克 BO-BD 后 4 小时内的急性耐受性、血液中的 BHB 和血糖浓度。两种份量和配方的 BO-BD 耐受性都很好,并能增加血液中的 BHB,诱导营养性酮症(≥ 0.5mM),这种情况一直持续到研究结束。酮病是剂量反应性的;在两种制剂中,25 克 BO-BD 的 BHB 浓度峰值(Cmax)和曲线下面积增量(iAUC)明显高于 12.5 克。不同配方之间的 Cmax 或 iAUC 没有明显差异。进餐后,所有条件下的血糖都会升高;不同条件下的血糖反应无明显差异。这些结果表明,新型 KE BO-BD 的粉末和饮料配方都能在健康的老年人中诱导酮病,这有助于今后研究这种成分对衰老的功能性影响。
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