Comparison of LED- and LASER-based fNIRS technologies to record the human peri‑spinal cord neurovascular response

IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Raúl Caulier-Cisterna , Juan-Pablo Appelgren-Gonzáles , Juan-Esteban Oyarzún , Felipe Valenzuela , Ranganatha Sitaram , Antonio Eblen-Zajjur , Sergio Uribe
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Abstract

Recently, functional Near-Infrared Spectroscopy (fNIRS) was applied to obtain, non-invasively, the human peri‑spinal Neuro-Vascular Response (NVR) under a non-noxious electrical stimulation of a peripheral nerve. This method allowed the measurements of changes in the concentration of oxyhemoglobin (O2Hb) and deoxyhemoglobin (HHb) from the peri‑spinal vascular network. However, there is a lack of clarity about the potential differences in perispinal NVR recorded by the different fNIRS technologies currently available. In this work, the two main noninvasive fNIRS technologies were compared, i.e., LED and LASER-based. The recording of the human peri‑spinal NVR induced by non-noxious electrical stimulation of a peripheral nerve was recorded simultaneously at C7 and T10 vertebral levels. The amplitude, rise time, and full width at half maximum duration of the perispinal NVRs were characterized in healthy volunteers and compared between both systems. The main difference was that the LED-based system shows about one order of magnitude higher values of amplitude than the LASER-based system. No statistical differences were found for rise time and for duration parameters (at thoracic level). The comparison of point-to-point wave patterns did not show significant differences between both systems. In conclusion, the peri‑spinal NRV response obtained by different fNIRS technologies was reproducible, and only the amplitude showed differences, probably due to the power of the system which should be considered when assessing the human peri‑spinal vascular network.

基于 LED 和激光的 fNIRS 技术在记录人体脊髓周围神经血管反应方面的比较
最近,有人应用功能性近红外光谱(fNIRS)技术,在对周围神经进行无毒电刺激的情况下,非侵入性地获取人体脊髓周围神经血管反应(NVR)。这种方法可以测量脊髓周围血管网络中氧合血红蛋白(O2Hb)和脱氧血红蛋白(HHb)浓度的变化。然而,目前可用的不同 fNIRS 技术所记录的脊髓周围 NVR 的潜在差异尚不明确。在这项研究中,我们比较了两种主要的无创 fNIRS 技术,即基于 LED 和激光的技术。在 C7 和 T10 椎骨水平同时记录了外周神经非毒性电刺激引起的人体脊柱周围 NVR。对健康志愿者脊髓周围无创电流的振幅、上升时间和半最大全宽持续时间进行了描述,并对两种系统进行了比较。主要区别在于,LED 系统的振幅值比激光系统高出约一个数量级。在上升时间和持续时间参数(胸腔水平)方面没有发现统计学差异。点对点波形的比较也未显示出两种系统之间的显著差异。总之,不同 fNIRS 技术获得的脊柱周围 NRV 反应具有可重复性,只有振幅显示出差异,这可能是由于系统的功率所致,在评估人体脊柱周围血管网络时应考虑到这一点。
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来源期刊
Medical Engineering & Physics
Medical Engineering & Physics 工程技术-工程:生物医学
CiteScore
4.30
自引率
4.50%
发文量
172
审稿时长
3.0 months
期刊介绍: Medical Engineering & Physics provides a forum for the publication of the latest developments in biomedical engineering, and reflects the essential multidisciplinary nature of the subject. The journal publishes in-depth critical reviews, scientific papers and technical notes. Our focus encompasses the application of the basic principles of physics and engineering to the development of medical devices and technology, with the ultimate aim of producing improvements in the quality of health care.Topics covered include biomechanics, biomaterials, mechanobiology, rehabilitation engineering, biomedical signal processing and medical device development. Medical Engineering & Physics aims to keep both engineers and clinicians abreast of the latest applications of technology to health care.
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