Intrinsic connectivity demonstrates a shared role of the posterior cingulate for cue reactivity in both gambling and cocaine use disorders

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors Pub Date : 2024-04-04 DOI:10.1016/j.addbeh.2024.108027

Anthony G. Vaccaro , Cheryl M. Lacadie , Marc N. Potenza

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引用次数: 0

Abstract

Cue reactivity is relevant across addictive disorders as a process relevant to maintenance, relapse, and craving. Understanding the neurobiological foundations of cue reactivity across substance and behavioral addictions has important implications for intervention development. The present study used intrinsic connectivity distribution methods to examine functional connectivity during a cue-exposure fMRI task involving gambling, cocaine and sad videos in 22 subjects with gambling disorder, 24 with cocaine use disorder, and 40 healthy comparison subjects. Intrinsic connectivity distribution implicated the posterior cingulate cortex (PCC) at a stringent whole-brain threshold. Post-hoc analyses investigating the nature of the findings indicated that individuals with gambling disorder and cocaine use disorder exhibited decreased connectivity in the posterior cingulate during gambling and cocaine cues, respectively, as compared to other cues and compared to other groups. Brain-related cue reactivity in substance and behavioral addictions involve PCC connectivity in a content-to-disorder specific fashion. The findings suggesting that PCC-related circuitry underlies cue reactivity across substance and behavioral addictions suggests a potential biomarker for targeting in intervention development.

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内在连通性表明后扣带回在赌博和可卡因使用障碍的线索反应中发挥着共同作用

线索反应性与成瘾性疾病相关，是与维持、复发和渴求相关的一个过程。了解物质成瘾和行为成瘾的线索反应性的神经生物学基础对干预措施的开发具有重要意义。本研究采用内在连通性分布方法，研究了 22 名赌博障碍受试者、24 名可卡因使用障碍受试者和 40 名健康对比受试者在涉及赌博、可卡因和悲伤视频的线索暴露 fMRI 任务中的功能连通性。在严格的全脑阈值下，内在连通性分布牵涉到后扣带回皮层（PCC）。对研究结果性质的事后分析表明，与其他线索和其他组别相比，赌博障碍患者和可卡因使用障碍患者在赌博和可卡因线索过程中分别表现出扣带回后部的连接性降低。药物成瘾和行为成瘾中与大脑相关的线索反应涉及扣带回连通性，这种连通性具有内容与障碍的特异性。研究结果表明，PCC 相关回路是物质成瘾和行为成瘾中线索反应性的基础，这为干预措施的开发提供了潜在的生物标记。

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来源期刊

Addictive behaviors 医学-药物滥用

CiteScore

8.40

自引率

4.50%

发文量

283

审稿时长

46 days

期刊介绍： Addictive Behaviors is an international peer-reviewed journal publishing high quality human research on addictive behaviors and disorders since 1975. The journal accepts submissions of full-length papers and short communications on substance-related addictions such as the abuse of alcohol, drugs and nicotine, and behavioral addictions involving gambling and technology. We primarily publish behavioral and psychosocial research but our articles span the fields of psychology, sociology, psychiatry, epidemiology, social policy, medicine, pharmacology and neuroscience. While theoretical orientations are diverse, the emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. However, innovative and empirically oriented case studies that might encourage new lines of inquiry are accepted as well. Studies that clearly contribute to current knowledge of etiology, prevention, social policy or treatment are given priority. Scholarly commentaries on topical issues, systematic reviews, and mini reviews are encouraged. We especially welcome multimedia papers that incorporate video or audio components to better display methodology or findings. Studies can also be submitted to Addictive Behaviors? companion title, the open access journal Addictive Behaviors Reports, which has a particular interest in ''non-traditional'', innovative and empirically-oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research.