A late eating midpoint is associated with increased risk of diabetic kidney disease: a cross-sectional study based on NHANES 2013-2020.

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2024-03-23 DOI:10.1186/s12937-024-00939-z

Chun-Feng Lu, Xiao-Min Cang, Wang-Shu Liu, Li-Hua Wang, Hai-Yan Huang, Xue-Qin Wang, Li-Hua Zhao, Feng Xu

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引用次数: 0

Abstract

Background: Modifying diet is crucial for diabetes and complication management. Numerous studies have shown that adjusting eating habits to align with the circadian rhythm may positively affect metabolic health. However, eating midpoint, eating duration, and their associations with diabetic kidney disease (DKD) are poorly understood.

Methods: The National Health and Nutrition Examination Survey (2013-2020) was examined for information on diabetes and dietary habits. From the beginning and ending times of each meal, we calculated the eating midpoint and eating duration. Urinary albumin-to-creatinine ratio (UACR) ≥ 30 mg/g and/or estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m² were the specific diagnostic criteria for DKD.

Results: In total, details of 2194 subjects with diabetes were collected for analysis. The overall population were divided into four subgroups based on the eating midpoint quartiles. The prevalence of DKD varied noticeably (P = 0.037) across the four categories. When comparing subjects in the second and fourth quartiles of eating midpoint to those in the first one, the odds ratios (ORs) of DKD were 1.31 (95% CI, 1.03 to 1.67) and 1.33 (95% CI, 1.05 to 1.70), respectively. And after controlling for potential confounders, the corresponding ORs of DKD in the second and fourth quartiles were 1.42 (95% CI, 1.07 to 1.90) and 1.39 (95% CI, 1.04 to 1.85), respectively.

Conclusions: A strong correlation was found between an earlier eating midpoint and a reduced incidence of DKD. Eating early in the day may potentially improve renal outcomes in patients with diabetes.

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进食中点晚与糖尿病肾病风险增加有关：基于 NHANES 2013-2020 的横断面研究。

背景：调整饮食对糖尿病和并发症的控制至关重要。大量研究表明，调整饮食习惯以适应昼夜节律可能会对代谢健康产生积极影响。然而，人们对进食中点、进食持续时间及其与糖尿病肾病（DKD）的关系知之甚少：方法：研究了全国健康与营养调查（2013-2020 年）中有关糖尿病和饮食习惯的信息。根据每餐的开始和结束时间，我们计算出进食中点和进食持续时间。尿白蛋白与肌酐比值（UACR）≥ 30 mg/g和/或估计肾小球滤过率（eGFR）2是糖尿病的具体诊断标准：共收集了 2194 名糖尿病患者的详细资料进行分析。根据饮食中点四分位数将总体人群分为四个亚组。DKD 的患病率在四个类别中存在明显差异（P = 0.037）。将饮食中点第二和第四四分位数的受试者与饮食中点第一四分位数的受试者进行比较，DKD的几率比（ORs）分别为1.31（95% CI，1.03至1.67）和1.33（95% CI，1.05至1.70）。在控制了潜在的混杂因素后，第二和第四个四分位数中 DKD 的相应 OR 分别为 1.42（95% CI，1.07 至 1.90）和 1.39（95% CI，1.04 至 1.85）：结论：进食中点越早，DKD发病率越低，两者之间存在很强的相关性。一天中较早进食有可能改善糖尿病患者的肾脏预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.