Periodontitis and osteoporosis: a two-sample Mendelian randomization analysis.

IF 1.9 4区 医学 Q2 BIOLOGY
Jiale Wu, Lihui Yao, Yuchen Liu, ShuaiShuai Zhang, Kan Wang
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引用次数: 0

Abstract

The incidences of periodontitis and osteoporosis are rising worldwide. Observational studies have shown that periodontitis is associated with increased risk of osteoporosis. We performed a Mendelian randomization (MR) study to genetically investigate the causality of periodontitis on osteoporosis. We explored the causal effect of periodontitis on osteoporosis by MR analysis. A total of 9 single nucleotide polymorphisms (SNP) were related to periodontitis. The primary approach in this MR analysis was the inverse variance-weighted (IVW) method. Simple median, weighted median, and penalized weighted median were used to analyze sensitivity. The fixed-effect IVW model and random-effect IVW model showed no significant causal effect of genetically predicted periodontitis on the risk of osteoporosis (OR=1.032; 95%CI: 0.923-1.153; P=0.574; OR=1.032; 95%CI: 0.920-1.158; P=0.588, respectively). Similar results were observed in simple mode (OR=1.031; 95%CI: 0.780-1.361, P=0.835), weighted mode (OR=1.120; 95%CI: 0.944-1.328, P=0.229), simple median (OR=1.003; 95%CI: 0.839-1.197, P=0.977), weighted median (OR=1.078; 95%CI: 0.921-1.262, P=0.346), penalized weight median (OR 1.078; 95%CI: 0.919-1.264, P=0.351), and MR-Egger method (OR=1.360; 95%CI: 0.998-1.853, P=0.092). There was no heterogeneity in the IVW and MR-Egger analyses (Q=7.454, P=0.489 and Q=3.901, P=0.791, respectively). MR-Egger regression revealed no evidence of a pleiotropic influence through genetic variants (intercept: -0.004; P=0.101). The leave-one-out sensitivity analysis indicated no driven influence of any individual SNP on the association between periodontitis and osteoporosis. The Mendelian randomization analysis did not show a significant detrimental effect of periodontitis on the risk of osteoporosis.

牙周炎与骨质疏松症:双样本孟德尔随机分析。
牙周炎和骨质疏松症的发病率在全球呈上升趋势。观察性研究表明,牙周炎与骨质疏松症风险的增加有关。我们进行了一项孟德尔随机化(MR)研究,从遗传学角度探讨牙周炎与骨质疏松症的因果关系。我们通过 MR 分析探讨了牙周炎对骨质疏松症的因果效应。共有 9 个单核苷酸多态性(SNP)与牙周炎有关。该磁共振分析的主要方法是反方差加权法(IVW)。简单中位法、加权中位法和惩罚加权中位法用于分析敏感性。固定效应 IVW 模型和随机效应 IVW 模型显示,基因预测的牙周炎对骨质疏松症风险没有显著的因果效应(OR=1.032;95%CI:0.923-1.153;P=0.574;OR=1.032;95%CI:0.920-1.158;P=0.588)。在简单模式(OR=1.031;95%CI:0.780-1.361,P=0.835)、加权模式(OR=1.120;95%CI:0.944-1.328,P=0.229)、简单中位数(OR=1.003;95%CI:0.839-1.197,P=0.977)、加权中位数(OR=1.078;95%CI:0.921-1.262,P=0.346)、惩罚性加权中位数(OR 1.078;95%CI:0.919-1.264,P=0.351)和 MR-Egger 法(OR=1.360;95%CI:0.998-1.853,P=0.092)。IVW和MR-Egger分析不存在异质性(分别为Q=7.454,P=0.489和Q=3.901,P=0.791)。MR-Egger回归显示,没有证据表明遗传变异会产生多向影响(截距:-0.004;P=0.101)。剔除敏感性分析表明,任何单个 SNP 对牙周炎与骨质疏松症之间的关联都没有驱动性影响。孟德尔随机分析未显示牙周炎对骨质疏松症风险有显著的不利影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.00
自引率
0.00%
发文量
129
审稿时长
2 months
期刊介绍: The Brazilian Journal of Medical and Biological Research, founded by Michel Jamra, is edited and published monthly by the Associação Brasileira de Divulgação Científica (ABDC), a federation of Brazilian scientific societies: - Sociedade Brasileira de Biofísica (SBBf) - Sociedade Brasileira de Farmacologia e Terapêutica Experimental (SBFTE) - Sociedade Brasileira de Fisiologia (SBFis) - Sociedade Brasileira de Imunologia (SBI) - Sociedade Brasileira de Investigação Clínica (SBIC) - Sociedade Brasileira de Neurociências e Comportamento (SBNeC).
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