Validity of the modified versions of SARC-F+EBM for sarcopenia screening and diagnosis in China: the PPLSS study.

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS
Jia-Yu Guo, Kang Yu, Chun-Wei Li, Yuan-Yuan Bao, Yu Zhang, Fang Wang, Rong-Rong Li, Hai-Yan Xie
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Abstract

Background and objectives: It is recommended by Asian Working Group for Sarcopenia to early identify people at risk for sarcopenia using simple screening tools like SARC-F. The modified version SARC-F+EBM showed higher diagnostic performance. However, this cut-off value of body mass index (BMI) remained uncertain to be used in Chinese population. In this study, we used appropriate BMI recommended for Chinese older population and further modified SARC-F+EBM by combining calf circumference.

Methods and study design: Diagnostic tests were performed and the receiver operating characteristics analyses were conducted between the SARC-F, SARC-F+EBM (cut-off of BMI: ≤ 21 kg/m2), SARC-F+EBM (CN) (cut-off of BMI: ≤ 22 kg/m2), SARC-CalF and SARC-CalF+EBM (CN) (cut-off of BMI: ≤ 22 kg/m2) in 1660 community-dwelling participants aged ≥ 65 years from China.

Results: The participants had an average age of 71.7±5.1 years, of which 56.8% were women. All the modified models could enhance the areas under the receiver operating characteristic curve (AUC) of original SARC-F (all p<0.001). The SARC-F+EBM (CN) also showed a significantly higher sensitivity of 47.4% (p<0.001) and an AUC of 0.809 (p=0.005) than SARC-F+EBM. SARC-CalF+EBM (CN) was validated to be of great diagnostic value of the highest AUC of 0.88 among these sarcopenia screening tools, including SARC-F, SARC-CalF and SARC-F+EBM (CN) (all p<0.001). Using this study population as a reference, the optimal cut-off value of SARC-CalF+EBM (CN) is ≥12 points, with a sensitivity of 79.3% and a specificity of 80.7%.

Conclusions: The SARC-F+EBM (CN) and SARC-CalF+EBM (CN) could enhance the diagnostic performance of SARC-F and SARC-F+EBM and are suitable sarcopenia screening tools for Chinese population.

中国肌少症筛查和诊断的 SARC-F+EBM 修订版的有效性:PPLSS 研究。
背景与目的:亚洲肌肉疏松症工作组建议使用简单的筛查工具(如 SARC-F)及早发现有肌肉疏松症风险的人群。改良版 SARC-F+EBM 显示出更高的诊断性能。然而,这一体重指数(BMI)临界值在中国人群中的应用仍不确定。在本研究中,我们采用了适合中国老年人群的推荐体重指数,并结合小腿围进一步修改了 SARC-F+EBM:对 1660 名年龄≥ 65 岁的中国社区居民进行了诊断测试,并对 SARC-F、SARC-F+EBM(BMI 临界值:≤ 21 kg/m2)、SARC-F+EBM (CN)(BMI 临界值:≤ 22 kg/m2)、SARC-CalF 和 SARC-CalF+EBM (CN)(BMI 临界值:≤ 22 kg/m2)进行了接收器操作特性分析:结果:参与者的平均年龄为(71.7±5.1)岁,其中女性占 56.8%。所有修改后的模型都能提高原始 SARC-F 的接收器操作特征曲线下面积(AUC)(所有 pC 结论:SARC-F+EBM、SARC-F+SARC-F+SARC-F+SARC-F+SARC-F+SARC-F+SARC-FSARC-F+EBM(CN)和 SARC-CalF+EBM (CN)可提高 SARC-F 和 SARC-F+EBM 的诊断性能,是适合中国人群的肌少症筛查工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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