Decaffeinated green tea polyphenols supplementation had no adverse health effects in girls with obesity: a randomized controlled trial.

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS
Die Yao, Luyao Xie, Kun Du, Xinyuan Yao, Xiuhua Shen
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Abstract

Background and objectives: While the health promoting effects of green tea polyphenols have been identi-fied among adult, research on children is scarce probably due to safety concerns about caffeine. This study aims to evaluate the safety of decaffeinated green tea polyphenols (DGTP) supplementation in girls with obesity and lay the foundation for its application in children population.

Methods and study design: This 12-week randomized, double-blinded, parallel-controlled trial was performed among 62 girls with obesity aged 6 to 10 years old. Participants were allocated to take 400 mg/d DGTP (DGTP group, n = 31) or isodose placebo (Control group, n = 31) at random. Anthropometric measurements and biochemical parameters including hepatic and renal function indicators, serum minerals concentrations, and routine blood parameters, were measured at baseline and the end of this trial. DGTP intake diary was required for each participant to record any abnormal reactions.

Results: After the 12-week supplementation, compared to Control group, the uric acid concentration in DGTP group showed a significant decrease (-48.0 ± 83.2 vs -0.01 ± 69.1, μmol/L), within the normal range. Regarding other biochemical indicators, there were no significant differences in changed values between the two groups. Throughout the trial, no adverse effects were reported in either group.

Conclusions: This study indicated that the supplementation of 400 mg/d DGTP for 12 weeks had no adverse health effects in girls with obesity, providing evidence for the DGTP adoption in children research.

补充低咖啡因绿茶多酚对肥胖女孩的健康无不良影响:随机对照试验。
背景和目的:虽然绿茶多酚对健康的促进作用已在成人中得到确认,但对儿童的研究却很少,这可能是出于对咖啡因安全性的担忧。本研究旨在评估肥胖女童补充低咖啡因绿茶多酚(DGTP)的安全性,并为其在儿童人群中的应用奠定基础:这项为期 12 周的随机、双盲、平行对照试验在 62 名 6 至 10 岁的肥胖症女孩中进行。参与者被随机分配到每天服用 400 毫克 DGTP(DGTP 组,n = 31)或等剂量安慰剂(对照组,n = 31)。在基线和试验结束时测量人体测量和生化指标,包括肝肾功能指标、血清矿物质浓度和常规血液指标。每位参与者都需要填写 DGTP 摄入日记,以记录任何异常反应:补充 12 周后,与对照组相比,DGTP 组的尿酸浓度显著下降(-48.0 ± 83.2 vs -0.01 ± 69.1,μmol/L),在正常范围内。至于其他生化指标,两组之间的变化值无明显差异。在整个试验过程中,两组均未出现不良反应:这项研究表明,连续 12 周每天补充 400 毫克 DGTP 不会对肥胖女孩的健康产生不良影响,为在儿童研究中采用 DGTP 提供了证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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