CFD simulation of cannabidiol delivery through microneedle patches.

IF 1.7 4区医学 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-07-01 Epub Date: 2024-03-10 DOI:10.1080/10255842.2024.2324881

Liqun Shi, Jianfeng Xu, Lihua Zhang, Weiping Zuo, Binbin Ni, Mingqiang Lai, Maoqi Fu

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引用次数: 0

Abstract

This study investigates the efficiency and influence of microneedle parameters, specifically Needle Point Angle (a) and Needle Height (h), on the diffusion of Cannabidiol (CBD) across varying skin depths. Utilizing the Latin Hypercube Sampling method, twelve distinct cases were analyzed. Observations reveal a consistent high concentration of CBD delivered via the microneedle patch, with a notable decrease in concentration as the depth increases, displaying a non-linear trend. Multivariate polynomial regression offers a quantitative relationship between the variables, with the third-order bivariate fitting providing the most accurate representation. Compared to other CBD delivery mechanisms, microneedle patches present enhanced CBD concentrations, circumventing challenges faced by other methods such as dosage inaccuracy, systemic absorption issues, and CBD degradation. The results highlight the potential of microneedle patches as a promising avenue for optimized transdermal drug delivery.

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通过微针贴片输送大麻二酚的 CFD 仿真。

本研究调查了微针参数（特别是针尖角度（a）和针高（h））对大麻二酚（CBD）在不同皮肤深度扩散的效率和影响。利用拉丁超立方取样法，对十二种不同的情况进行了分析。观察结果显示，通过微针贴片输送的大麻二酚浓度一直很高，随着深度的增加，浓度明显下降，呈现非线性趋势。多变量多项式回归提供了变量之间的定量关系，三阶二变量拟合提供了最准确的表述。与其他 CBD 给药机制相比，微针贴片提高了 CBD 浓度，避免了其他方法面临的挑战，如剂量不准确、系统吸收问题和 CBD 降解。研究结果凸显了微针贴片作为优化透皮给药途径的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Computer Methods in Biomechanics and Biomedical Engineering 工程技术-工程：生物医学

CiteScore

4.10

自引率

6.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： The primary aims of Computer Methods in Biomechanics and Biomedical Engineering are to provide a means of communicating the advances being made in the areas of biomechanics and biomedical engineering and to stimulate interest in the continually emerging computer based technologies which are being applied in these multidisciplinary subjects. Computer Methods in Biomechanics and Biomedical Engineering will also provide a focus for the importance of integrating the disciplines of engineering with medical technology and clinical expertise. Such integration will have a major impact on health care in the future.