Optimizing exposure data collection for plant protection products: identifying ideal collectors with the fluorescent dye pyranine

IF 1.4 3区农林科学 Q4 FOOD SCIENCE & TECHNOLOGY

Journal of Consumer Protection and Food Safety Pub Date : 2024-03-05 DOI:10.1007/s00003-024-01498-5

Annika Ehmke, Jens Karl Wegener, Andreas Melfsen, Eberhard Hartung

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Abstract

When approving plant protection products, exposure data are required for risk analysis. Exposure data can be collected for various exposure pathways, such as dermal, inhalation or ground sediment. For measuring exposures, pyranine, a fluorescent dye, and a collector can be used. However, the choice of collector material depends on the specific exposure pathway. This study aims to determine the most suitable collector, in combination with the tracer pyranine, for recording exposure through different pathways in practical trials.

Seven different collectors (Tyvek^®, labels, plastic patches, paper patches, nylon filters, fibreglass filters, petri dishes) were subjected to laboratory and field tests to assess various quality parameters. Blank values, recovery rates, storability, and fluorescence degradation under UV-radiation were measured. Based on the results, a matrix was created summarizing which collector might be best suited to capture each exposure pathway. Almost all collectors demonstrated high recovery rates (Tyvek^® 100%; labels 100%; plastic patches 100%; paper patches 100%; nylon filters 95%; fiberglass filters 60.9%) as well as good storability. Furthermore, all plastic-based collectors (labels, Tyvek^®, plastic patches, petri dishes) showed a very good recovery rate above 95% when exposed to UV-radiation. However, nylon filters were not suitable for utilization under field conditions due to the rapid degradation of fluorescence under UV-radiation (recovery rate: 20–56%). Nevertheless, nylon filters showed stable recoveries under protected conditions and can be used to assess inhalation exposures under these conditions. Fibreglass filters, with recovery rates of 84–86%, were well-suited for testing inhalative exposures outdoors when a correction factor was applied. Tyvek^® was the most suitable material for detecting total dermal exposure under field conditions. This is due to its quality characteristics and availability in a variety of sizes. Finally, petri dishes were ideal for collecting ground sediments.

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优化植物保护产品的暴露数据收集：利用荧光染料吡喃确定理想的收集器

在批准植物保护产品时，需要接触数据来进行风险分析。可以收集各种暴露途径的暴露数据，如皮肤、吸入或地面沉积物。在测量暴露时，可以使用吡喃染料、荧光染料和收集器。不过，收集器材料的选择取决于具体的暴露途径。七种不同的收集器（特卫强®、标签、塑料贴片、纸贴片、尼龙过滤器、玻璃纤维过滤器、培养皿）经过了实验室和现场测试，以评估各种质量参数。对空白值、回收率、储存性和紫外线照射下的荧光降解进行了测量。根据测试结果，创建了一个矩阵，总结出哪种收集器最适合捕捉每种暴露途径。几乎所有收集器都表现出较高的回收率（特卫强® 100%；标签 100%；塑料贴片 100%；纸贴片 100%；尼龙过滤器 95%；玻璃纤维过滤器 60.9%）和良好的储存性。此外，所有基于塑料的收集器（标签、特卫强®、塑料贴片、培养皿）在紫外线照射下的回收率都超过了 95%。不过，尼龙过滤器在紫外线照射下荧光会迅速衰减（回收率：20-56%），因此不适合在野外条件下使用。不过，尼龙过滤器在受保护的条件下显示出稳定的恢复率，可用于评估在这些条件下的吸入辐照。玻璃纤维过滤器的回收率为 84-86%，在应用校正因子时非常适合用于室外吸入辐照测试。特卫强® 是最适合在野外条件下检测皮肤总暴露量的材料。这归功于其质量特性和各种尺寸的可用性。最后，培养皿是收集地面沉积物的理想材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Consumer Protection and Food Safety Veterinary-Food Animals

CiteScore

3.70

自引率

4.20%

发文量

审稿时长

>12 weeks

期刊介绍： The JCF publishes peer-reviewed original Research Articles and Opinions that are of direct importance to Food and Feed Safety. This includes Food Packaging, Consumer Products as well as Plant Protection Products, Food Microbiology, Veterinary Drugs, Animal Welfare and Genetic Engineering. All peer-reviewed articles that are published should be devoted to improve Consumer Health Protection. Reviews and discussions are welcomed that address legal and/or regulatory decisions with respect to risk assessment and management of Food and Feed Safety issues on a scientific basis. It addresses an international readership of scientists, risk assessors and managers, and other professionals active in the field of Food and Feed Safety and Consumer Health Protection. Manuscripts – preferably written in English but also in German – are published as Research Articles, Reviews, Methods and Short Communications and should cover aspects including, but not limited to: · Factors influencing Food and Feed Safety · Factors influencing Consumer Health Protection · Factors influencing Consumer Behavior · Exposure science related to Risk Assessment and Risk Management · Regulatory aspects related to Food and Feed Safety, Food Packaging, Consumer Products, Plant Protection Products, Food Microbiology, Veterinary Drugs, Animal Welfare and Genetic Engineering · Analytical methods and method validation related to food control and food processing. The JCF also presents important News, as well as Announcements and Reports about administrative surveillance.