{"title":"The intestinal delivery systems of ferulic acid: Absorption, metabolism, influencing factors, and potential applications","authors":"Yushan Chen, Wendi Teng, Jinpeng Wang, Ying Wang, Yuemei Zhang, Jinxuan Cao","doi":"10.1002/fft2.366","DOIUrl":null,"url":null,"abstract":"<p>Ferulic acid (FA) is a hydroxycinnamic acid known for its strong antioxidant activity and potential benefits for intestinal health. However, its poor water solubility and instability limit its effectiveness. To address these issues, different ways have been explored to protect FA against degradation and further exert its potential benefits. This review discusses the absorption and metabolism of FA in the gut, as well as its potential impact on intestinal health. It also compares different intestinal delivery systems, such as nanoparticles, electrospun nanofibers, microcapsules, cross-linked polymer gels, and Pickering emulsions, which can improve the solubility, stability, and bioavailability of FA in the gastrointestinal tract. This comprehensive review provides valuable insights for using FA in food, pharmaceutical, and nutraceuticals products.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":null,"pages":null},"PeriodicalIF":7.4000,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.366","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food frontiers","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/fft2.366","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Ferulic acid (FA) is a hydroxycinnamic acid known for its strong antioxidant activity and potential benefits for intestinal health. However, its poor water solubility and instability limit its effectiveness. To address these issues, different ways have been explored to protect FA against degradation and further exert its potential benefits. This review discusses the absorption and metabolism of FA in the gut, as well as its potential impact on intestinal health. It also compares different intestinal delivery systems, such as nanoparticles, electrospun nanofibers, microcapsules, cross-linked polymer gels, and Pickering emulsions, which can improve the solubility, stability, and bioavailability of FA in the gastrointestinal tract. This comprehensive review provides valuable insights for using FA in food, pharmaceutical, and nutraceuticals products.
阿魏酸（FA）是一种羟基肉桂酸，以其强大的抗氧化活性和对肠道健康的潜在益处而闻名。然而，阿魏酸的水溶性差和不稳定性限制了它的功效。为了解决这些问题，人们探索了不同的方法来保护脂肪酸不被降解，并进一步发挥其潜在功效。本综述将讨论脂肪酸在肠道中的吸收和代谢及其对肠道健康的潜在影响。它还比较了不同的肠道给药系统，如纳米颗粒、电纺纳米纤维、微胶囊、交联聚合物凝胶和皮克林乳剂，这些系统可以提高 FA 在胃肠道中的溶解度、稳定性和生物利用率。本综述为在食品、药品和保健品中使用 FA 提供了宝贵的见解。
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