Decision-making ability limitations and brain neural activity changes in healthcare workers after mild COVID-19

IF 2.4 4区 医学 Q3 NEUROSCIENCES
Yaotian Gao , Keyi Lin , Bangyue Wang , Wei Ji , Jia Liu , Mengcheng Du , Wei Wang , Yan Li , Xiaowen Du , Yuyang Wang , Tao Jiang
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引用次数: 0

Abstract

Studies have demonstrated that the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) extensively affects brain function. Although cognitive dysfunction is considered a common manifestation in COVID-19 patients during the recovery period, the potential changes in decision-making ability, are not yet clear. Decision-making functions are essential to the work of healthcare workers. However, there is a lack of a multidimensional assessment of its functioning in COVID-19 cases. Here, we used tests combined with the resting-state functional magnetic resonance imaging (rs-fMRI) stabilization feature amplitude of low-frequency fluctuations (ALFF) to explore decision-making behavior and brain neural activity changes in healthcare workers after mild COVID-19. Participants were divided into the SARS-CoV-2 infected group (SI, n = 41) and healthy controls (HC, n = 42). All participants underwent a series of neuropsychological tests. They performed the Iowa Gambling Task (IGT) and the Game of Dice Task (GDT), followed by fMRI (n = 20) to assess their decision-making ability under ambiguous and risky conditions and changes in brain neural activity. The SI group performed worse in verbal memory than the HC group. Furthermore, the SI group performed worse in the IGT, whereas no significant difference was observed in the GDT. In addition, rs-fMRI showed enhanced spontaneous neural activity in the postcentral gyrus and inferior parietal lobe in the SI group compared to the HC group.

医护人员在轻度 COVID-19 后的决策能力限制和脑神经活动变化。
研究表明,新型严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)会广泛影响大脑功能。虽然认知功能障碍被认为是 COVID-19 患者在恢复期的常见表现,但决策能力的潜在变化尚不清楚。决策功能对医护人员的工作至关重要。然而,目前还缺乏对 COVID-19 病例决策功能的多维度评估。在此,我们使用静息态功能磁共振成像(rs-fMRI)稳定特征低频波动幅度(ALFF)测试来探讨轻度 COVID-19 后医护人员的决策行为和脑神经活动变化。参与者分为 SARS-CoV-2 感染组(SI,n = 41)和健康对照组(HC,n = 42)。所有参与者都接受了一系列神经心理学测试。他们进行了爱荷华赌博任务(IGT)和骰子游戏任务(GDT),然后进行了 fMRI(n = 20),以评估他们在模糊和危险条件下的决策能力以及大脑神经活动的变化。与 HC 组相比,SI 组在言语记忆方面表现更差。此外,SI 组在 IGT 中的表现更差,而在 GDT 中未观察到显著差异。此外,rs-fMRI 显示,与 HC 组相比,SI 组中央后回和顶叶下部的自发神经活动增强。
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来源期刊
Neuroscience Research
Neuroscience Research 医学-神经科学
CiteScore
5.60
自引率
3.40%
发文量
136
审稿时长
28 days
期刊介绍: The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.
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