The role of stimulant washout status in functional connectivity of default mode and fronto-parietal networks in children with neurodevelopmental conditions

IF 2.9 2区医学 Q1 EDUCATION, SPECIAL

Research in Developmental Disabilities Pub Date : 2024-02-09 DOI:10.1016/j.ridd.2024.104691

Kelsey Harkness , Signe Bray , Kara Murias

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引用次数: 0

Abstract

Background

Stimulant medication is the primary pharmacological treatment for attention dysregulation and is commonly prescribed for children with Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism. Neuroimaging studies of these groups commonly use a 24–48-hour washout period to mediate the effects of stimulant medication on functional connectivity (FC) metrics. However, the impact of washout on functional connectivity has received limited study.

Methods

We used fMRI data from participants with diagnosis of Autism and ADHD (and an off stimulant control) from the Adolescent Brain and Cognitive Development (ABCD) and Autism Brain Imaging Data Exchange (ABIDE) databases to explore the effect of simulant washout on FC. Connectivity within and between the default mode (DMN) and fronto-parietal networks (FPN) was examined, as these networks have previously been implicated in attention dysregulation and associated with stimulant medication usage. For each diagnostic group, we assessed effects in interconnectivity between DMN and FPN, intraconnectivity within DMN, and intraconnectivity within FPN.

Results

We found no significant effect of medication status in intra- and inter-connectivity of the DMN and the FPN in either diagnostic group.

Implications

Our findings suggest that more information is needed about the effect of stimulant medication, and washout, on the FC of attention networks in clinical populations.

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兴奋剂冲洗状态在神经发育障碍儿童默认模式和前顶叶网络功能连接中的作用

背景兴奋剂是治疗注意力障碍的主要药物，通常用于治疗注意力缺陷/多动障碍（ADHD）和自闭症儿童。针对这些群体的神经影像学研究通常使用24-48小时的冲洗期来调解兴奋剂药物对功能连接（FC）指标的影响。我们利用青少年脑与认知发展（ABCD）和自闭症脑成像数据交换（ABIDE）数据库中被诊断为自闭症和多动症（ADHD）的参与者（以及未服用兴奋剂的对照组）的fMRI数据，探讨模拟药物休药期对FC的影响。我们研究了默认模式（DMN）和前顶叶网络（FPN）内部和之间的连接性，因为这些网络以前曾被认为与注意力失调有关，并与兴奋剂药物的使用相关。对于每个诊断组，我们评估了DMN和FPN之间的相互连接性、DMN内部的相互连接性以及FPN内部的相互连接性的影响。结果我们发现，在任何一个诊断组中，药物状态对DMN和FPN的内部和相互连接性都没有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in Developmental Disabilities Multiple-

CiteScore

5.50

自引率

6.50%

发文量

178

期刊介绍： Research In Developmental Disabilities is aimed at publishing original research of an interdisciplinary nature that has a direct bearing on the remediation of problems associated with developmental disabilities. Manuscripts will be solicited throughout the world. Articles will be primarily empirical studies, although an occasional position paper or review will be accepted. The aim of the journal will be to publish articles on all aspects of research with the developmentally disabled, with any methodologically sound approach being acceptable.

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