Mobile sleep EEG suggests delayed brain maturation in adolescents with ADHD: A focus on oscillatory spindle frequency

IF 2.9 2区医学 Q1 EDUCATION, SPECIAL

Research in Developmental Disabilities Pub Date : 2024-02-07 DOI:10.1016/j.ridd.2024.104693

Blanka Vojnits , Tárek Zoltán Magyar , Orsolya Szalárdy , Vivien Reicher , Mária Takács , Nóra Bunford , Róbert Bódizs

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Abstract

Background

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Although data show ADHD is associated with sleep problems, approaches to analyze the association between ADHD and sleep electrophysiology are limited to a few methods with circumscribed foci.

Aims

Sleep EEG was analyzed by a mixed-radix FFT routine and power spectrum parametrization in adolescents with ADHD and adolescents not at-risk for ADHD. Spectral components of sleep EEG were analyzed employing a novel, model-based approach of EEG power spectra.

Methods and procedures

The DREEM mobile polysomnography headband was used to record home sleep EEG from 19 medication-free adolescents with ADHD and 29 adolescents not at-risk for ADHD (overall: N = 56, age range 14–19 years) and groups were compared on characteristics of NREM sleep.

Outcomes and results

Adolescents with ADHD exhibited lower frequency of spectral peaks indicating sleep spindle oscillations whereas adolescents not at-risk for ADHD showed lower spectral power in the slow sleep spindle and beta frequency ranges.

Conclusions and implications

The observed between-groups difference might indicate delayed brain maturity unraveled during sleep in ADHD.

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移动睡眠脑电图显示多动症青少年的大脑成熟延迟：关注振荡纺锤频率

背景注意缺陷/多动障碍（ADHD）是一种普遍存在的神经发育障碍。尽管有数据显示ADHD与睡眠问题有关，但分析ADHD与睡眠电生理学之间关联的方法却仅限于少数几种具有限定病灶的方法。目的对患有ADHD的青少年和无ADHD风险的青少年的睡眠脑电图进行了混合梯度FFT常规分析和功率谱参数化分析。方法和程序使用 DREEM 移动多导睡眠监测头带记录 19 名未服药的多动症青少年和 29 名非多动症高危青少年（总人数：56 人，年龄范围 14-19 岁）的家庭睡眠脑电图，并比较各组的 NREM 睡眠特征。结果表明，患有多动症的青少年显示出较低的频谱峰频率，表明睡眠纺锤振荡，而非多动症高危青少年在慢速睡眠纺锤和β频率范围内显示出较低的频谱功率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in Developmental Disabilities Multiple-

CiteScore

5.50

自引率

6.50%

发文量

178

期刊介绍： Research In Developmental Disabilities is aimed at publishing original research of an interdisciplinary nature that has a direct bearing on the remediation of problems associated with developmental disabilities. Manuscripts will be solicited throughout the world. Articles will be primarily empirical studies, although an occasional position paper or review will be accepted. The aim of the journal will be to publish articles on all aspects of research with the developmentally disabled, with any methodologically sound approach being acceptable.

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