PRE-DIAGNOSTIC MANIFESTATIONS OF ALZHEIMER'S DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF LONGITUDINAL STUDIES

medRxiv - Geriatric Medicine Pub Date : 2024-01-31 DOI:10.1101/2024.01.31.24301944

Sedigheh Zabihi, Rosario Isabel Espinoza Jeraldo, Rifah Anjum, Christine Carter, Moïse Roche, Jonathan P Bestwick, Sarah Morgan-Trimmer, Yvonne Birks, Mark Wilberforce, Fiona M Walter, Claudia Cooper, Charles R Marshall

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Abstract

Alzheimer's disease (AD) is associated with a range of non-cognitive symptoms that can be early or even presenting features. Better recognition of pre-diagnostic symptoms of AD would support improved early detection and diagnosis. To identify possible prodromal symptoms of AD, we systematically searched electronic databases for prospective longitudinal studies to March 2023, that reported the risk of AD diagnosis associated with non-cognitive symptoms. We conducted random-effects meta-analyses to obtain pooled odds of subsequent AD. Thirty studies met eligibility criteria. Most studies (n=18) reported on the association of depression with subsequent AD diagnosis (pooled OR= 1.80; 95% CI: 1.29 to 2.50; I2=95.8%). Hearing loss, weight loss, spondylosis and hypotension also predicted a subsequent AD diagnosis. This evidence suggests that these features that may be recorded during routine healthcare encounters are risk markers for incident AD and could therefore support improved early detection and diagnosis.

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阿尔茨海默病的诊断前表现：纵向研究的系统回顾和荟萃分析

阿尔茨海默病（AD）与一系列非认知症状有关，这些症状可能是早期特征，甚至是表现特征。更好地识别阿尔茨海默病的诊断前症状将有助于改善早期检测和诊断。为了识别可能的老年痴呆症前驱症状，我们在电子数据库中系统地搜索了截至 2023 年 3 月的前瞻性纵向研究，这些研究报告了与非认知症状相关的老年痴呆症诊断风险。我们进行了随机效应荟萃分析，以获得后续注意力缺失症的集合几率。有 30 项研究符合资格标准。大多数研究（18 项）报告了抑郁症与继发性注意力缺失症诊断的相关性（汇总 OR=1.80；95% CI：1.29 至 2.50；I2=95.8%）。听力下降、体重减轻、脊椎病和低血压也可预测随后的注意力缺失症诊断。这些证据表明，这些在日常医疗保健过程中可能会被记录下来的特征是导致注意力缺失症发生的风险标志物，因此可以帮助改善早期发现和诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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medRxiv - Geriatric Medicine

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