The cognitive impact of light: illuminating ipRGC circuit mechanisms

Abstract

Ever-present in our environments, light entrains circadian rhythms over long timescales, influencing daily activity patterns, health and performance. Increasing evidence indicates that light also acts independently of the circadian system to directly impact physiology and behaviour, including cognition. Exposure to light stimulates brain areas involved in cognition and appears to improve a broad range of cognitive functions. However, the extent of these effects and their mechanisms are unknown. Intrinsically photosensitive retinal ganglion cells (ipRGCs) have emerged as the primary conduit through which light impacts non-image-forming behaviours and are a prime candidate for mediating the direct effects of light on cognition. Here, we review the current state of understanding of these effects in humans and mice, and the tools available to uncover circuit-level and photoreceptor-specific mechanisms. We also address current barriers to progress in this area. Current and future efforts to unravel the circuits through which light influences cognitive functions may inform the tailoring of lighting landscapes to optimize health and cognitive function. A direct influence of light exposure on cognition and behaviour, beyond that associated with circadian rhythms, has been reported. Mahoney and Schmidt consider the evidence for light’s effects on aspects of cognitive neurobehavioural performance, summarize current understanding of the underlying cellular and circuit mechanisms and point to future directions for this field of research.