Repetitive transcranial magnetic stimulation alleviates depression in a young patient with CADASIL: A case report

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology Pub Date : 2023-12-22 DOI:10.1016/j.jnrt.2023.100093

Mengru Qi , Mengke Ban , Zhaoyang Lu , Shuwen Cao , Ranran Yang , Ping Zhang , Jinggui Song

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引用次数: 0

Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a relatively common inherited arterial smooth muscle cell disease. The genetic defect is localized to the notch homolog protein 3 (NOTCH3) gene on chromosome 19q12 and is due to a missense variant in NOTCH3. The main clinical manifestations are transient ischemic attacks and repeated stroke, with cognitive impairments leading to dementia, migraine with aura, and mental/emotional disorders. To date, there is no specific therapeutic option, with only symptomatic supportive treatment for the symptoms of acute stroke, migraine, dementia, and mental abnormalities. Here, we provide a case report of a Chinese patient with CADASIL and a mutation in exon 4 of the NOTCH3 gene (p.Arg133Cys). The patient mainly exhibited recurrent cerebral infarction and affective disorder. Antidepressant treatment combined with repetitive transcranial magnetic stimulation significantly improved the depressive symptoms of the patient.

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重复经颅磁刺激缓解了 CADASIL 年轻患者的抑郁：病例报告

脑常染色体显性动脉病伴有皮层下梗塞和白质脑病（CADASIL）是一种相对常见的遗传性动脉平滑肌细胞病。该病的基因缺陷位于染色体19q12上的NOTCH同源蛋白3（NOTCH3）基因，是由NOTCH3的一个错义变体引起的。主要临床表现为短暂性脑缺血发作和反复中风，认知障碍导致痴呆、先兆偏头痛和精神/情感障碍。迄今为止，尚无特效治疗方案，只能对急性中风、偏头痛、痴呆和精神异常等症状进行对症支持治疗。在此，我们提供了一例中国 CADASIL 患者的病例报告，该患者患有 NOTCH3 基因第 4 外显子突变（p.Arg133Cys）。患者主要表现为复发性脑梗死和情感障碍。抗抑郁剂治疗结合重复经颅磁刺激，明显改善了患者的抑郁症状。

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来源期刊

Journal of Neurorestoratology CLINICAL NEUROLOGY-

CiteScore

2.10

自引率

18.20%

发文量

审稿时长

12 weeks