Application of dose-gradient function in reducing radiation induced lung injury in breast cancer radiotherapy.

IF 1.7 3区医学 Q3 INSTRUMENTS & INSTRUMENTATION

Journal of X-Ray Science and Technology Pub Date : 2024-01-01 DOI:10.3233/XST-230198

Han Bai, Hui Song, Qianyan Li, Jie Bai, Ru Wang, Xuhong Liu, Feihu Chen, Xiang Pan

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引用次数: 0

Abstract

Objective: Try to create a dose gradient function (DGF) and test its effectiveness in reducing radiation induced lung injury in breast cancer radiotherapy.

Materials and methods: Radiotherapy plans of 30 patients after breast-conserving surgery were included in the study. The dose gradient function was defined as DGH=VDVp3, then the area under the DGF curve of each plan was calculated in rectangular coordinate system, and the minimum area was used as the trigger factor, and other plans were triggered to optimize for area reduction. The dosimetric parameters of target area and organs at risk in 30 cases before and after re-optimization were compared.

Results: On the premise of ensuring that the target dose met the clinical requirements, the trigger factor obtained based on DGF could further reduce the V5, V10, V20, V30 and mean lung dose (MLD) of the ipsilateral lung in breast cancer radiotherapy, P < 0.01. And the D2cc and mean heart dose (MHD) of the heart were also reduced, P < 0.01. Besides, the NTCPs of the ipsilateral lung and the heart were also reduced, P < 0.01.

Conclusion: The trigger factor obtained based on DGF is efficient in reducing radiation induced lung injury in breast cancer radiotherapy.

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在乳腺癌放疗中应用剂量梯度函数减少辐射引起的肺损伤。

目的尝试创建剂量梯度函数（DGF），并测试其在减少乳腺癌放疗中辐射诱导肺损伤方面的有效性：研究纳入了 30 例保乳手术后患者的放疗计划。将剂量梯度函数定义为 DGH=VDVp3，然后在矩形坐标系下计算每个计划的 DGF 曲线下面积，并以最小面积作为触发因子，触发其他计划以优化减少面积。比较了重新优化前后 30 个病例的靶区和危险器官的剂量学参数：结果：在保证靶区剂量满足临床要求的前提下，基于 DGF 得出的触发因子可进一步降低乳腺癌放疗中同侧肺的 V5、V10、V20、V30 和平均肺剂量（MLD），P < 0.01。心脏的D2cc和平均心脏剂量（MHD）也有所降低，P＜0.01。此外，同侧肺和心脏的NTCPs也有所降低，P＜0.01：基于 DGF 得出的触发因子可有效减少乳腺癌放疗中辐射诱导的肺损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of X-Ray Science and Technology 工程技术-光学

CiteScore

4.90

自引率

23.30%

发文量

150

审稿时长

3 months

期刊介绍： Research areas within the scope of the journal include: Interaction of x-rays with matter: x-ray phenomena, biological effects of radiation, radiation safety and optical constants X-ray sources: x-rays from synchrotrons, x-ray lasers, plasmas, and other sources, conventional or unconventional Optical elements: grazing incidence optics, multilayer mirrors, zone plates, gratings, other diffraction optics Optical instruments: interferometers, spectrometers, microscopes, telescopes, microprobes