Unraveling the link between childhood maltreatment and depression: Insights from the role of ventral striatum and middle cingulate cortex in hedonic experience and emotion regulation.

IF 3.1 2区 心理学 Q2 PSYCHOLOGY, DEVELOPMENTAL
Development and Psychopathology Pub Date : 2025-02-01 Epub Date: 2024-01-05 DOI:10.1017/S0954579423001591
Han-Yu Zhou, Lan Zhou, Tong-Xuan Zheng, Li-Ping Ma, Ming-Xia Fan, Liang Liu, Xu-Dong Zhao, Chao Yan
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引用次数: 0

Abstract

Childhood maltreatment is an established risk factor for psychopathology. However, it remains unclear how childhood traumatic events relate to mental health problems and how the brain is involved. This study examined the serial mediation effect of brain morphological alterations and emotion-/reward-related functions on linking the relationship from maltreatment to depression. We recruited 156 healthy adolescents and young adults and an additional sample of 31 adolescents with major depressive disorder for assessment of childhood maltreatment, depressive symptoms, cognitive reappraisal and anticipatory/consummatory pleasure. Structural MRI data were acquired to identify maltreatment-related cortical and subcortical morphological differences. The mediation models suggested that emotional maltreatment of abuse and neglect, was respectively associated with increased gray matter volume in the ventral striatum and greater thickness in the middle cingulate cortex. These structural alterations were further related to reduced anticipatory pleasure and disrupted cognitive reappraisal, which contributed to more severe depressive symptoms among healthy individuals. The above mediating effects were not replicated in our clinical group partly due to the small sample size. Preventative interventions can target emotional and reward systems to foster resilience and reduce the likelihood of future psychiatric disorders among individuals with a history of maltreatment.

解开童年虐待与抑郁症之间的联系:腹侧纹状体和中扣带回皮层在享乐体验和情绪调节中的作用。
童年虐待是导致精神病理学的一个既定风险因素。然而,童年创伤事件与心理健康问题的关系以及大脑是如何参与其中的,目前仍不清楚。本研究考察了大脑形态学改变和情绪/奖赏相关功能对连接虐待与抑郁之间关系的序列中介效应。我们招募了156名健康的青少年和年轻成年人以及31名患有重度抑郁障碍的青少年样本,对他们进行了童年虐待、抑郁症状、认知再评价和预期/消费性愉悦的评估。研究人员获取了结构性核磁共振成像数据,以确定与虐待相关的皮层和皮层下形态差异。中介模型表明,虐待和忽视等情绪虐待分别与腹侧纹状体灰质体积增加和中扣带回皮层厚度增加有关。这些结构性改变还与预期愉悦感的降低和认知重评的中断有关,而这两种情况导致了健康人更严重的抑郁症状。在我们的临床小组中,上述中介效应没有得到复制,部分原因是样本量较小。预防性干预措施可以针对情感和奖赏系统,以培养有虐待史的人的复原力,降低他们未来患精神疾病的可能性。
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来源期刊
Development and Psychopathology
Development and Psychopathology PSYCHOLOGY, DEVELOPMENTAL-
CiteScore
7.20
自引率
9.10%
发文量
319
期刊介绍: This multidisciplinary journal is devoted to the publication of original, empirical, theoretical and review papers which address the interrelationship of normal and pathological development in adults and children. It is intended to serve and integrate the field of developmental psychopathology which strives to understand patterns of adaptation and maladaptation throughout the lifespan. This journal is of interest to psychologists, psychiatrists, social scientists, neuroscientists, paediatricians, and researchers.
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