Effects of sleep deprivation on cortical excitability: A threshold-tracking TMS study and review of the literature

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2024-01-01 DOI:10.1016/j.cnp.2023.12.001

Magdalena Mroczek , Amedeo de Grado , Hossain Pia , Zahra Nochi , Hatice Tankisi

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引用次数: 0

Abstract

Objective

Insufficient sleep is linked to several health problems. Previous studies on the effects of sleep deprivation on cortical excitability using conventional transcranial magnetic stimulation (TMS) included a limited number of modalities, and few inter-stimulus intervals (ISIs) and showed conflicting results. This study aimed to investigate the effects of sleep deprivation on cortical excitability through threshold-tracking TMS, using a wide range of protocols at multiple ISIs.

Methods

Fifteen healthy subjects (mean age ± SD: 36 ± 3.34 years) were included. The following tests were performed before and after 24 h of sleep deprivation using semi-automated threshold-tacking TMS protocols: short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) at 11 ISIs between 1 and 30 ms, short interval intracortical facilitation (SICF) at 14 ISIs between 1 and 4.9 ms, long interval intracortical inhibition (LICI) at 6 ISIs between 50 and 300 ms, and short-latency afferent inhibition (SAI) at 12 ISIs between 16 and 30 ms.

Results

No significant differences were observed between pre- and post-sleep deprivation measurements for SICI, ICF, SICF, or LICI at any ISIs (p < 0.05). As for SAI, we found a difference at 28 ms (p = 0.007) and 30 ms (p = 0.04) but not at other ISIs.

Conclusions

Sleep deprivation does not affect cortical excitability except for SAI.

Significance

This study confirms some of the previous studies while contradicting others.

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剥夺睡眠对大脑皮层兴奋性的影响：阈值追踪 TMS 研究和文献综述

目的睡眠不足与多种健康问题有关。以往使用传统经颅磁刺激（TMS）研究睡眠不足对大脑皮层兴奋性的影响时，采用的刺激模式和刺激间隔（ISI）有限，结果也相互矛盾。本研究旨在通过阈值追踪 TMS，在多个 ISIs 下使用多种方案，研究睡眠剥夺对大脑皮层兴奋性的影响。在剥夺睡眠 24 小时之前和之后，使用半自动阈值跟踪 TMS 方案进行了以下测试：1 至 30 毫秒之间 11 个 ISI 的短间隔皮层内抑制（SICI）和皮层内促进（ICF）、1 至 4.9 毫秒之间 14 个 ISI 的短间隔皮层内促进（SICF）、长间隔皮层内抑制（SICI）和皮层内促进（ICF）。结果在任何 ISIs 的 SICI、ICF、SICF 或 LICI 方面，睡眠剥夺前后的测量结果均未观察到显著差异（p < 0.05）。结论除 SAI 外，睡眠剥夺不会影响大脑皮层的兴奋性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.