Object-place-context learning impairment correlates with spatial learning impairment in aged Long–Evans rats

IF 2.4 3区 医学 Q3 NEUROSCIENCES
Hippocampus Pub Date : 2023-12-11 DOI:10.1002/hipo.23591
Yuxi Chen, Audrey Branch, Cecelia Shuai, Michela Gallagher, James J. Knierim
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Abstract

The hippocampal formation is vulnerable to the process of normal aging. In humans, the extent of this age-related deterioration varies among individuals. Long–Evans rats replicate these individual differences as they age, and therefore they serve as a valuable model system to study aging in the absence of neurodegenerative diseases. In the Morris water maze, aged memory-unimpaired (AU) rats navigate to remembered goal locations as effectively as young rats and demonstrate minimal alterations in physiological markers of synaptic plasticity, whereas aged memory-impaired (AI) rats show impairments in both spatial navigation skills and cellular and molecular markers of plasticity. The present study investigates whether another cognitive domain is affected similarly to navigation in aged Long–Evans rats. We tested the ability of young, AU, and AI animals to recognize novel object-place-context (OPC) configurations and found that performance on the novel OPC recognition paradigm was significantly correlated with performance on the Morris water maze. In the first OPC test, young and AU rats, but not AI rats, successfully recognized and preferentially explored objects in novel OPC configurations. In a second test with new OPC configurations, all age groups showed similar OPC associative recognition memory. The results demonstrated similarities in the behavioral expression of associative, episodic-like memory between young and AU rats and revealed age-related, individual differences in functional decline in both navigation and episodic-like memory abilities.

物体-空间-情境学习障碍与老年长耳大鼠的空间学习障碍有关
海马体形成容易受到正常衰老过程的影响。在人类中,这种与年龄相关的退化程度因人而异。长伊万斯大鼠在衰老过程中复制了这些个体差异,因此它们是在没有神经退行性疾病的情况下研究衰老的宝贵模型系统。在莫里斯水迷宫中,记忆力未受损(AU)的老年大鼠与年轻大鼠一样能有效地导航到记忆中的目标位置,并且在突触可塑性的生理标志物方面表现出最小的改变,而记忆力受损(AI)的老年大鼠在空间导航技能以及可塑性的细胞和分子标志物方面都表现出损伤。本研究调查了老龄 Long-Evans 大鼠的另一个认知领域是否会受到与导航类似的影响。我们测试了幼年、AU 和 AI 动物识别新型物体-空间-情境(OPC)配置的能力,发现新型 OPC 识别范式的表现与 Morris 水迷宫的表现显著相关。在第一次OPC测试中,幼鼠和AU大鼠(而非AI大鼠)能成功识别并优先探索新的OPC配置中的物体。在第二项新OPC配置测试中,所有年龄组的大鼠都表现出了相似的OPC联想识别记忆。研究结果表明,年轻大鼠和非智力大鼠在联想记忆、类表象记忆的行为表现上具有相似性,并揭示了与年龄相关的个体差异,即导航和类表象记忆能力的功能衰退。
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来源期刊
Hippocampus
Hippocampus 医学-神经科学
CiteScore
5.80
自引率
5.70%
发文量
79
审稿时长
3-8 weeks
期刊介绍: Hippocampus provides a forum for the exchange of current information between investigators interested in the neurobiology of the hippocampal formation and related structures. While the relationships of submitted papers to the hippocampal formation will be evaluated liberally, the substance of appropriate papers should deal with the hippocampal formation per se or with the interaction between the hippocampal formation and other brain regions. The scope of Hippocampus is wide: single and multidisciplinary experimental studies from all fields of basic science, theoretical papers, papers dealing with hippocampal preparations as models for understanding the central nervous system, and clinical studies will be considered for publication. The Editor especially encourages the submission of papers that contribute to a functional understanding of the hippocampal formation.
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