Regional brain activity of resting-state fMRI and auditory oddball ERP with multimodal approach in individuals with internet gaming disorder.

IF 6.6 1区 医学 Q1 PSYCHIATRY
Journal of Behavioral Addictions Pub Date : 2023-11-21 Print Date: 2023-12-22 DOI:10.1556/2006.2023.00063
Minkyung Park, Joon Hwan Jang, So Young Yoo, Areum Choi, Heejung Kim, Jung-Seok Choi
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引用次数: 0

Abstract

Background and aims: Resting-state brain activity may be associated with the ability to perform tasks; however, a multimodal approach involving resting-state functional magnetic resonance imaging (fMRI) and event-related potentials (ERPs) has not been widely used to investigate addictive disorders.

Methods: We explored resting-state fMRI and auditory oddball ERP values from 26 with internet gaming disorder (IGD) patients and 27 age- and intelligence quotient-matched healthy controls (HCs). To assess the characteristics of resting-state fMRI, we calculated regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional amplitude of low-frequency fluctuation (fALFF); we also calculated the P3 component of the ERPs.

Results: Compared with HCs, the individuals with IGD exhibited significant decreases in ReHo and fALFF values in the left inferior occipital gyrus, increased ReHo and ALFF values in the right precuneus, increased ALFF in the left superior frontal gyrus, and lower P3 amplitudes in the midline centro-parietal area during the auditory ERP task. Furthermore, the regional activity of resting-state fMRI in the right inferior temporal gyrus and the occipital regions were positively correlated with the P3 amplitudes in IGD patients, whereas ReHo values of the left hippocampus and the right amygdala were negatively correlated with P3.

Discussion and conclusions: Our results suggest that IGD patients have difficulty interacting effectively with cognitive function and sensory processing, although its interpretations need some cautions. The findings in this study will broaden the overall understanding of the neurobiological mechanisms that underlie IGD pathophysiology.

网络游戏障碍患者静息状态fMRI和多模态听觉古怪ERP脑区活动的研究。
背景和目的:静息状态下的大脑活动可能与执行任务的能力有关;然而,包括静息状态功能磁共振成像(fMRI)和事件相关电位(ERPs)在内的多模态方法尚未广泛用于研究成瘾性疾病。方法:对26例网络游戏障碍(IGD)患者和27例年龄和智商匹配的健康对照(hc)进行静息态功能磁共振成像(fMRI)和听觉古怪ERP值的检测。为了评估静息状态fMRI的特征,我们计算了区域均匀性(ReHo)、低频波动幅度(ALFF)和低频波动分数幅度(fALFF);我们还计算了erp的P3部分。结果:与正常人相比,IGD组在听觉ERP任务中表现出左侧枕下回ReHo和fALFF值明显降低,右侧叶前叶ReHo和ALFF值明显升高,左侧额上回ALFF值明显升高,顶叶中线中央区P3振幅明显降低。IGD患者静息状态fMRI右侧颞下回和枕部区域的区域活动与P3波幅呈正相关,而左侧海马和右侧杏仁核的ReHo值与P3呈负相关。讨论和结论:我们的研究结果表明,IGD患者难以有效地与认知功能和感觉加工相互作用,尽管其解释需要一些谨慎。本研究的发现将扩大对IGD病理生理学基础的神经生物学机制的全面理解。
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来源期刊
CiteScore
12.30
自引率
7.70%
发文量
91
审稿时长
20 weeks
期刊介绍: The aim of Journal of Behavioral Addictions is to create a forum for the scientific information exchange with regard to behavioral addictions. The journal is a broad focused interdisciplinary one that publishes manuscripts on different approaches of non-substance addictions, research reports focusing on the addictive patterns of various behaviors, especially disorders of the impulsive-compulsive spectrum, and also publishes reviews in these topics. Coverage ranges from genetic and neurobiological research through psychological and clinical psychiatric approaches to epidemiological, sociological and anthropological aspects.
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