Metastasis suppressor genes and their role in the tumor microenvironment.

IF 7.7 2区医学 Q1 ONCOLOGY

Cancer and Metastasis Reviews Pub Date : 2023-12-01 Epub Date: 2023-11-20 DOI:10.1007/s10555-023-10155-6

Cristina Megino-Luque, Jose Javier Bravo-Cordero

引用次数: 0

Abstract

The metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells at metastatic sites. Within this complex process, several genes have been identified as metastasis suppressors, playing a role in the inhibition of metastasis. Interestingly, some of these genes have been shown to also play a role in regulating the tumor microenvironment. In this review, we comment on the recent developments in the biology of metastasis suppressor genes and their crosstalk with the microenvironment.

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转移抑制基因及其在肿瘤微环境中的作用。

转移级联是一个复杂的过程，涉及多种因素，有助于癌细胞在转移部位的播种和生长。在这个复杂的过程中，一些基因被确定为转移抑制因子，在抑制转移中发挥作用。有趣的是，其中一些基因也被证明在调节肿瘤微环境中发挥作用。本文就肿瘤转移抑制基因的生物学研究进展及其与微环境的相互作用作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer and Metastasis Reviews 医学-肿瘤学

CiteScore

17.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms.The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments. A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.