Application of nanogold-cisplatin drug delivery system in laryngeal cancer chemoradiotherapy

Abstract

To evaluate the efficacy of nanoparticle-loaded cisplatin (DDP) for treating laryngeal cancer (LC), we developed a delivery system for targeted DDP delivery using gold nanoparticles (GNPs). FaDu cells were cultured to assess the permeability and antitumor efficacy of DDP@GNP, and an LC rat model was constructed to further investigate its antitumor efficiency. In vitro experiments revealed that the DDP@GPN had a particle size ranging from 80–90 nm and significantly prolonged the half-life of DDP by nearly 50-fold. Additionally, DDP@GNP demonstrated excellent targeting and penetration ability in FaDu cells, thereby effectively enhancing apoptosis and inhibiting the invasive properties of tumor cells. Furthermore, DDP@GNP enhanced the radiosensitivity of FaDu cells, thus enhancing the efficacy of radiotherapy. In vivo experiments also showed that the combination of DDP@GNP with radiotherapy significantly reduced tumor volume. Therefore, DDP@GNP shows immense potential for enhancing the efficacy of chemoradiotherapy in LC.