Sensitivity, specificity and positive predictive value of ALEX2 multiplex examination in patients suffering from atopic dermatitis and reaction to tomatoes

IF 1.7 3区农林科学 Q3 CHEMISTRY, APPLIED

Food and Agricultural Immunology Pub Date : 2023-10-03 DOI:10.1080/09540105.2023.2257398

Jarmila Čelakovská, Eva Čermákova, Radka Vaňková, Petra Boudková, Ctirad Andrýs, Jan Krejsek

引用次数: 0

Abstract

The aim of the study is to evaluate the clinical reactions to tomatoes in atopic dermatitis (AD) patients, and to analyse the results of specific IgE to allergens of tomatoes and to molecular components of pollen, seeds, fruits, vegetables and latex with the use of ALEX2 Allergy Xplorer test. According to our results, 15% of AD patients suffer from clinical reactions to tomatoes; we confirmed the low sensitivity and low positive predictive value of specific IgE to molecular component Sola l 6 and allergen extract Sola l, the specificity of this test is higher. The significantly higher sensitisation to other nonspecific lipid transfer proteins is observed in patients sensitised to tomato allergens. An elimination diet and an exposure test are recommended to detect a reaction to tomatoes. ALEX2 Allergy Xplorer test gives us a comprehensive picture of sensitisation and the possibility of evaluation of cross-reacting allergens.

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ALEX2多重检查在特应性皮炎及番茄反应患者中的敏感性、特异性及阳性预测值

本研究的目的是评价异位性皮炎(AD)患者对番茄的临床反应，并利用ALEX2过敏Xplorer试验分析对番茄过敏原及花粉、种子、水果、蔬菜和乳胶分子成分的特异性IgE的检测结果。根据我们的研究结果，15%的AD患者对西红柿有临床反应;我们证实了特异性IgE对分子成分sola116和过敏原提取物sola116的低敏感性和低阳性预测值，该试验的特异性较高。在对番茄过敏原敏感的患者中，观察到对其他非特异性脂质转移蛋白显着更高的致敏性。建议采用消除饮食和接触试验来检测对西红柿的反应。ALEX2过敏Xplorer测试为我们提供了一个全面的致敏图片和评估交叉反应过敏原的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food and Agricultural Immunology 农林科学-毒理学

CiteScore

5.30

自引率

6.70%

发文量

审稿时长

2 months

期刊介绍： Food and Agricultural Immunology is an international open access journal publishing original immunological research with applications in food, agricultural, environmental and veterinary science. Submissions describing the use of immunological techniques and methods are particularly welcomed. The journal aims to expand our understanding of the interactions at the interface of food and immune systems including studies on: -Development of diagnostic systems – all types of ligand-based assays, e.g. antibody, aptamer -Application of ligand-based assays for the detection or identification of molecules of interest in food science, agricultural research, veterinary investigations and clinical systems relating to food allergy or sensitivity to agricultural chemicals -Effects of food on the immune system -Studies on allergy and allergic reactions -Investigations into food allergies -Development of allergen-free food systems -Development of novel assay formats -Applications of assay systems to the monitoring of food items in relation to safety and labelling -Food quality issues, e.g. speciation, adulteration and contamination -Comparisons between different analytical techniques The journal publishes research and review articles and is essential reading for food scientists, immunologists and all those concerned with the interaction between food and immune systems.