Modeling and simulation of the first phase of the viscoelastic biological particles considering simultaneous roughness of tip, particle, and substrate

Z. Rastegar
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引用次数: 1

Abstract

In recent years, atomic force microscopy as a basic tool for nanoparticles displacement and manufacturing of intended subjects from atoms and molecules has attracted researchers in different fields such as drug delivery, tissue engineering and etc. Manipulation simulation of the AFM nanorobot is a fundamental tool for controlled and accurate displacement of subjects and particles in different scales. Since passing from macro to micro and nanoscales causes the increased ratio of the area to volume consequently surface forces such as friction and adhesion become more important. According to the surface roughness in contact, critical time and force have been extracted in this paper considering particle and substrate roughness simultaneously to find out the effect of the surface roughness on critical parameters. Therefore, developed rough models for viscoelastic state have been used and asperities radius using experimental test on cancer cells has been extracted to increase simulation accuracy. Results show that the critical force for the elastic, rough viscoelastic and viscoelastic models have higher magnitudes respectively. This difference between elastic and viscoelastic models are completely obvious but between two viscoelastic models are less.
考虑尖端、颗粒和基底同时粗糙度的粘弹性生物颗粒第一阶段的建模与仿真
近年来,原子力显微镜作为纳米粒子置换和原子分子制造目标物体的基本工具,吸引了药物输送、组织工程等不同领域的研究人员。AFM纳米机器人的操纵仿真是实现物体和粒子在不同尺度上的精确位移控制的基础工具。由于从宏观到微观和纳米尺度的过渡导致面积与体积的比例增加,因此表面力(如摩擦力和附着力)变得更加重要。根据接触表面粗糙度,同时考虑颗粒和基体粗糙度,提取临界时间和临界力,找出表面粗糙度对临界参数的影响。因此,利用已建立的粘弹性状态粗糙模型,提取癌细胞实验测试的凹凸半径,提高模拟精度。结果表明,弹性模型、粗粘弹性模型和粘弹性模型的临界力分别具有较高的量级。弹性模型与粘弹性模型之间的这种差异是完全明显的,而粘弹性模型与粘弹性模型之间的差异则较小。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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