THE EFFECT OF EGGPLANT JUICE TO THE THICKNESS OF AORTIC WALL IN WHITE RAT

Jurnal Teknologi Pangan dan Gizi Pub Date : 2021-10-01 DOI:10.33508/JTPG.V20I2.3174

I. Dwijayanti

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Abstract

Atherosclerosis is a complex chronic disease characterized by the accumulation of lipids within arterial walls. Delphinidin-3-(p-coumaroylrutinoside)-5-glucoside (nasunin), an anthocyanin, was isolated as purple-colored crystals from eggplant peels. Nasunin protection against induced lipid peroxidation in rat. The aim of study was to determine the effect of eggplant juice to the thickness of aortic wall of white rat with atherogenic diet. This true experimental laboratoric study using control group post test design performed in white rat that placed in pharmacologic laboratory of Brawijaya University. Sampling was carried out by completely random sampling with 25 rats for the total sample. Data were processed and analyzed using SPSS 16. Statistical test using one-way ANOVA and continuing with post hoc Tukey. The result showed there was a significant effect between positive control of diet atherogenic with the dosage I (1,3 gr/3 ml), dosage II (2,6 gr/3 ml), and dosage III (5,2 gr/3 ml) of eggplant juice to aorta wall thickness (p=0,000;p<0,05) . We can conclude that the effective dosage of eggplant juice for reducing the progression of aortic wall thickening is dosage III (5,2 gr/3 ml).

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茄子汁对大鼠主动脉壁厚度的影响

动脉粥样硬化是一种以动脉壁内脂质积累为特征的复杂慢性疾病。从茄子皮中分离得到了花色苷类物质Delphinidin-3-(p-coumaroylrutinoside)-5-glucoside (nasunin)。纳苏宁对大鼠脂质过氧化的保护作用。本研究旨在探讨茄子汁对致动脉粥样硬化大鼠主动脉壁厚度的影响。本实验采用巴西布拉维贾亚大学药理学实验室大鼠为实验对象，采用对照组后测设计。抽样采用完全随机抽样，总样本25只。使用SPSS 16对数据进行处理和分析。统计检验采用单因素方差分析，并继续采用事后方差分析。结果表明，茄汁剂量I (1,3 gr/3 ml)、剂量II (2,6 gr/3 ml)、剂量III (5,2 gr/3 ml)对饮食性动脉粥样硬化的阳性对照对主动脉壁厚度有显著影响(p= 0000;p< 0.05)。我们可以得出结论，茄子汁减缓主动脉壁增厚进展的有效剂量为剂量III (5,2 gr/ 3ml)。

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Jurnal Teknologi Pangan dan Gizi

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