Bio/chemical microsystem designed for wafer scale testing

Abstract

We have designed a bio/chemical microsystem for online monitoring of glucose concentrations during fermentation. The system contains several passive microfluidic components including an enzyme reactor, a flow lamination part and a detector. Detection is based on the reaction of hydrogen peroxide, that is produced from glucose in an enzyme reactor, with luminol. This chemiluminescent reaction generates light that is detected by an integrated back-side contacted photodiode array. Various tests during fabrication are outlined with the emphasis on microwave detected photo conductance decay. The presented microsystem has both fluidic and electrical connection points accessible from the backside. This allows simultaneous testing of both fluidic and electrical parts before dicing the wafer.