Melanoma-associated retinopathy with anti-TRPM1 autoantibodies showing concomitant Off-bipolar cell dysfunction.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Documenta Ophthalmologica Pub Date : 2022-12-01 DOI:10.1007/s10633-022-09901-y

Wei-Che Hung, Hui-Chen Cheng, An-Guor Wang

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引用次数: 2

Abstract

Background: To report the clinical features of a patient with melanoma-associated retinopathy (MAR) with anti-transient receptor potential cation channel, subfamily M, member 1 (TRPM1) autoantibodies showing concomitant Off-bipolar cell dysfunction.

Methods: We evaluated a patient with a past history of scalp melanoma presented with sudden-onset shimmering photopsia in both eyes. MAR was confirmed with complete ophthalmic examinations, electronegative electroretinogram (ERG), and the presence of anti-TRPM1 autoantibodies by Western blot analysis. S-cone ERG and photopic On-Off ERG were studied in this patient as well.

Results: The patient's best-corrected visual acuity was 6/30 in the right eye and 6/8.6 in the left eye. Fundus and OCT findings were unremarkable. Visual field test showed severe constriction in both eyes. His full-field ERG was electronegative. S-cone ERG recorded preservation of L/M-cone-mediated response and undetectable S-cone-mediated response. Photopic On-Off ERG disclosed attenuated On- and Off-response. Western blot analysis confirmed immunoreactivity of the patient's serum to a 30 kDa TRPM1 recombinant protein. Whole-body positron emission tomography scan detected lymph node metastases in the neck.

Conclusions: Anti-TRPM1 autoantibody-positive MAR varies greatly in its presentation and clinical course. We present a case of anti-TRPM1 autoantibody-positive MAR with atypical feature of Off-bipolar cell involvement. A complete electroretinographic study together with identification of the pathogenic antiretinal autoantibodies may help better understand and subclassify the disease in the future.

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黑色素瘤相关视网膜病变伴抗trpm1自身抗体，伴有Off-bipolar细胞功能障碍。

背景:报道1例伴有抗瞬时受体电位离子通道M亚家族成员1 (TRPM1)自身抗体的黑色素瘤相关视网膜病变(MAR)患者的临床特征，该患者伴有Off-bipolar细胞功能障碍。方法:我们评估了一名既往有头皮黑色素瘤病史的患者，该患者表现为双眼突发性闪光性失光。通过完整的眼科检查、电负性视网膜电图(ERG)和Western blot分析抗trpm1自身抗体的存在证实了MAR。同时观察s锥ERG和光敏开关ERG。结果:患者最佳矫正视力为右眼6/30，左眼6/8.6。眼底及OCT检查无明显差异。视野检查显示双眼严重收缩。全场电图呈电负性。S-cone ERG记录了L/ m -cone介导的反应和无法检测到的S-cone介导的反应的保存。光电开关ERG揭示了衰减的开关响应。Western blot分析证实患者血清对30kda的TRPM1重组蛋白具有免疫反应性。全身正电子发射断层扫描发现颈部淋巴结转移。结论:抗trpm1自身抗体阳性MAR的表现和临床病程差异很大。我们提出了一例抗trpm1自身抗体阳性MAR与非典型特征的双极细胞累及。一个完整的视网膜电图研究和鉴定致病性抗视网膜自身抗体可能有助于更好地了解和细分疾病在未来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Documenta Ophthalmologica 医学-眼科学

CiteScore

3.50

自引率

21.40%

发文量

审稿时长

>12 weeks

期刊介绍： Documenta Ophthalmologica is an official publication of the International Society for Clinical Electrophysiology of Vision. The purpose of the journal is to promote the understanding and application of clinical electrophysiology of vision. Documenta Ophthalmologica will publish reviews, research articles, technical notes, brief reports and case studies which inform the readers about basic and clinical sciences related to visual electrodiagnosis and means to improve diagnosis and clinical management of patients using visual electrophysiology. Studies may involve animals or humans. In either case appropriate care must be taken to follow the Declaration of Helsinki for human subject or appropriate humane standards of animal care (e.g., the ARVO standards on Animal Care and Use).