Towards a better understanding of non-exudative choroidal and macular neovascularization

IF 18.6 1区医学 Q1 OPHTHALMOLOGY

Progress in Retinal and Eye Research Pub Date : 2023-01-01 DOI:10.1016/j.preteyeres.2022.101113

Riccardo Sacconi , Serena Fragiotta , David Sarraf , SriniVas R. Sadda , K. Bailey Freund , Mariacristina Parravano , Giulia Corradetti , Diogo Cabral , Vittorio Capuano , Alexandra Miere , Eliana Costanzo , Francesco Bandello , Eric Souied , Giuseppe Querques

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引用次数: 12

Abstract

Non-exudative macular and choroidal neovascularization (MNV and CNV) usually refers to the entity of treatment-naïve type 1 neovascularization in the absence of associated signs of exudation. Histopathological studies, dating back in the early 70s, identified the presence of non-exudative MNV, but the first clinical report of this finding was in the late 90s using indocyanine green angiography in eyes with age-related macular degeneration (AMD). With more advanced retinal imaging, there has been an ever increasing appreciation of non-exudative MNV associated with AMD and CNV with other macular disorders. However, consensus regarding the exact definition and the clinical management of this entity is lacking. Furthermore, there may be variation in the imaging features and clinical course suggesting that a spectrum of disease may exist. Herein, we review the large body of published work that has provided a better understanding of non-exudative MNV and CNV in the last decade. The prevalence, multimodal imaging features, clinical course, and response to treatment are discussed to elucidate further key insights about this entity. Based on these observations, this review also proposes a new theory about the origin and course of different sub-types of non-exudative MNV/CNV which can have different etiologies and pathways according to the clinical context of disease.

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为了更好地了解非渗出性脉络膜和黄斑新生血管

非渗出性黄斑和脉络膜新生血管(MNV和CNV)通常是指在没有相关渗出体征的情况下treatment-naïve 1型新生血管的实体。早在70年代早期的组织病理学研究就发现了非渗出性MNV的存在，但这一发现的第一个临床报告是在90年代末使用靛绿血管造影术对患有年龄相关性黄斑变性(AMD)的眼睛进行的。随着视网膜成像技术的发展，与AMD相关的非渗出性MNV和与其他黄斑疾病相关的CNV越来越受到重视。然而，关于这个实体的确切定义和临床管理的共识是缺乏的。此外，在影像学特征和临床病程上可能存在差异，表明可能存在疾病谱系。在此，我们回顾了在过去十年中提供了对非渗出性MNV和CNV更好理解的大量已发表的工作。患病率，多模态影像特征，临床过程和治疗反应进行了讨论，以阐明进一步的关键见解关于这个实体。基于这些观察结果，本文还提出了关于非渗出性MNV/CNV不同亚型的起源和病程的新理论，这些亚型根据疾病的临床背景可能具有不同的病因和途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Retinal and Eye Research 医学-眼科学

CiteScore

34.10

自引率

5.10%

发文量

期刊介绍： Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists. The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.