Macular Vascular Complexity Analysis of Diabetes Mellitus by Swept-Source Optical Coherence Tomographic Angiography.

IF 2.1 4区医学 Q2 OPHTHALMOLOGY

Ophthalmologica Pub Date : 2022-01-01 DOI:10.1159/000528073

Jiahui Liu, Shuhui Chen, Zhiyi Xu, Wei Wang, Dingqiao Wang, Yongyue Su, Shulun Zhao, Meichan Li, Fengling Chen, Wenyong Huang, Chengguo Zuo, Minyu Chen

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引用次数: 1

Abstract

Purpose: This study was designed to evaluate the associations between retinal vascular complexity features, including fractal dimension (FD) and blood vessel tortuosity (BVT), and the severity of diabetic retinopathy (DR) by using optical coherence tomographic angiography (OCTA).

Methods: In this prospective cross-sectional study, 1,282 ocular-treatment-naive patients with type 2 diabetes mellitus (DM) (1,059 without DR and 223 with DR) registered in the community of Guangzhou, China, were enrolled. OCTA was used to measure FD and BVT in the superficial capillary plexus (SCP) and the deep capillary plexus (DCP). Univariate and multivariate linear regression analyses were performed to analyze the correlation of FD and BVT in different layers with DR severity.

Results: In this study, 1,282 patients with DM (1,282 eyes), with a mean age of 64.2 ± 7.8 years, were included. FD in the DCP decreased and BVT in the DCP increased in patients with DR compared with those in patients without DR, even after adjusting for confounding factors (p < 0.05). Trend analysis showed a significant decrease in the FD values as the DR progressed, whereas the BVT progressively increased with worsening DR severity (p < 0.01). The FD in DCP had a statistically significant positive correlation with FD in SCP and a negative correlation with BVT in SCP and BVT in DCP in all of the participants, including the non-DR group, moderate DR group, and severe DR group (p < 0.01).

Conclusions: FD and BVT determined using OCTA might be useful parameters for objectively distinguishing DR from non-DR and indicating DR progression.

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扫描源光学相干层析血管成像分析糖尿病黄斑血管复杂性。

目的:本研究旨在通过光学相干断层血管成像(OCTA)评估视网膜血管复杂性特征，包括分形维数(FD)和血管扭曲度(BVT)与糖尿病视网膜病变(DR)严重程度的关系。方法:在这项前瞻性横断面研究中，纳入了中国广州社区登记的1282例未接受眼科治疗的2型糖尿病(DM)患者(1059例无DR, 223例有DR)。用OCTA测量浅毛细血管丛(SCP)和深毛细血管丛(DCP)的FD和BVT。采用单因素和多因素线性回归分析，分析不同层次FD和BVT与DR严重程度的相关性。结果:本研究纳入DM患者1282例(1282只眼)，平均年龄64.2±7.8岁。即使在校正混杂因素后，DR患者与无DR患者相比，DCP FD降低，BVT升高(p < 0.05)。趋势分析显示，随着DR的进展，FD值显著降低，而BVT随着DR严重程度的加重而逐渐增加(p < 0.01)。所有被试(包括非DR组、中度DR组和重度DR组)的DCP FD与SCP FD呈显著正相关，与SCP BVT和DCP BVT呈显著负相关(p < 0.01)。结论:利用OCTA测定FD和BVT可能是客观区分DR与非DR和指示DR进展的有用参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmologica 医学-眼科学

CiteScore

5.10

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Published since 1899, ''Ophthalmologica'' has become a frequently cited guide to international work in clinical and experimental ophthalmology. It contains a selection of patient-oriented contributions covering the etiology of eye diseases, diagnostic techniques, and advances in medical and surgical treatment. Straightforward, factual reporting provides both interesting and useful reading. In addition to original papers, ''Ophthalmologica'' features regularly timely reviews in an effort to keep the reader well informed and updated. The large international circulation of this journal reflects its importance.