Effectiveness of a two-stage strategy using the 16-item Prodromal Questionnaire (PQ16/fPQ16) and the Comprehensive Assessment of At Risk Mental States (CAARMS) in the early detection of Ultra High Risk (UHR) patients in Lebanon: a cross-sectional pilot study

IF 1.2 4区医学 Q4 NEUROSCIENCES

Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique Pub Date : 2024-02-01 DOI:10.1016/j.encep.2022.11.006

M. Mourad , E.P. Atallah , G. Raad , R. Haddad , S. Richa

{"title":"Effectiveness of a two-stage strategy using the 16-item Prodromal Questionnaire (PQ16/fPQ16) and the Comprehensive Assessment of At Risk Mental States (CAARMS) in the early detection of Ultra High Risk (UHR) patients in Lebanon: a cross-sectional pilot study","authors":"M. Mourad , E.P. Atallah , G. Raad , R. Haddad , S. Richa","doi":"10.1016/j.encep.2022.11.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>This study aims to identify the prevalence of Ultra High Risk (UHR) adults in a sample of patients in Lebanon and to compare screening and diagnostic tools.</p></div><div><h3>Methods</h3><p>This is a cross-sectional pilot study which targeted patients aged 17–30 years willingly seeking psychiatric care in a university hospital in Beirut, Lebanon. Participants were invited to fill either the English or the French version of the Prodromal Questionnaire (respectively, PQ16 or fPQ16). The abbreviated version of the “Comprehensive Assessment of At-Risk Mental States” (CAARMS) was then administered to all participants. The latter were subsequently sorted into one of the three UHR groups – vulnerability group, attenuated psychosis (APS), intermittent psychosis (BLIPS) – or were diagnosed as suffering from a psychotic disorder.</p></div><div><h3>Results</h3><p>Thirty-one patients participated in this study. The prevalence of positive screening on the PQ16/fPQ16 and positive diagnosis of UHR on the CAARMS were respectively of 61.29% and 45%. The APS group was the most prevalent (71.42%). A positive psychosis screening on PQ16/fPQ16 was statistically related to a UHR diagnosis on CAARMS (<em>p</em>-value: 0.011 on Chi<sup>2</sup> test), OR=8.5 (95% CI: 1.4–50.9; <em>p</em>-value: 0.018). No relation was found between PQ16/fPQ16 results and risk stratification or between the number of “True” responses on PQ16/fPQ16 and the intensity of symptoms on CAARMS. PQ16/fPQ16 statements 5, 9, 11 and 16 predicted a UHR diagnosis on CAARMS (<em>p</em>-value of 0.045, 0.006, 0.045 and 0.045, respectively).</p></div><div><h3>Conclusion</h3><p>This two-stage strategy for identifying UHR patients can be adopted in a tertiary health care center.</p></div>","PeriodicalId":51042,"journal":{"name":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0013700622002755","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

This study aims to identify the prevalence of Ultra High Risk (UHR) adults in a sample of patients in Lebanon and to compare screening and diagnostic tools.

Methods

This is a cross-sectional pilot study which targeted patients aged 17–30 years willingly seeking psychiatric care in a university hospital in Beirut, Lebanon. Participants were invited to fill either the English or the French version of the Prodromal Questionnaire (respectively, PQ16 or fPQ16). The abbreviated version of the “Comprehensive Assessment of At-Risk Mental States” (CAARMS) was then administered to all participants. The latter were subsequently sorted into one of the three UHR groups – vulnerability group, attenuated psychosis (APS), intermittent psychosis (BLIPS) – or were diagnosed as suffering from a psychotic disorder.

Results

Thirty-one patients participated in this study. The prevalence of positive screening on the PQ16/fPQ16 and positive diagnosis of UHR on the CAARMS were respectively of 61.29% and 45%. The APS group was the most prevalent (71.42%). A positive psychosis screening on PQ16/fPQ16 was statistically related to a UHR diagnosis on CAARMS (p-value: 0.011 on Chi² test), OR = 8.5 (95% CI: 1.4–50.9; p-value: 0.018). No relation was found between PQ16/fPQ16 results and risk stratification or between the number of “True” responses on PQ16/fPQ16 and the intensity of symptoms on CAARMS. PQ16/fPQ16 statements 5, 9, 11 and 16 predicted a UHR diagnosis on CAARMS (p-value of 0.045, 0.006, 0.045 and 0.045, respectively).

Conclusion

This two-stage strategy for identifying UHR patients can be adopted in a tertiary health care center.

查看原文本刊更多论文

使用 16 项前驱症状问卷 (PQ16/fPQ16) 和高危精神状态综合评估 (CAARMS) 的两阶段策略对早期发现黎巴嫩超高危 (UHR) 患者的有效性：一项横断面试点研究

本研究旨在确定黎巴嫩样本患者中超高危（UHR）成人的患病率，并对筛查和诊断工具进行比较。方法这是一项横断面试点研究，研究对象是黎巴嫩贝鲁特一所大学医院中愿意寻求精神科治疗的 17-30 岁患者。参与者受邀填写英文版或法文版的前驱症状问卷（分别为 PQ16 或 fPQ16）。然后，对所有参与者进行简略版 "高危精神状态综合评估"（CAARMS）。后者随后被分为三个 UHR 群体之一--易感群体、减弱性精神病（APS）、间歇性精神病（BLIPS）--或被诊断为患有精神病性障碍。PQ16/fPQ16筛查阳性率和CAARMS UHR诊断阳性率分别为61.29%和45%。APS 组的发病率最高（71.42%）。PQ16/fPQ16 的精神病筛查阳性与 CAARMS 的 UHR 诊断有统计学关系（Chi2 检验的 p 值：0.011），OR = 8.5（95% CI：1.4-50.9；p 值：0.018）。在 PQ16/fPQ16 结果与风险分层之间，或在 PQ16/fPQ16 的 "正确 "回答数量与 CAARMS 的症状强度之间，均未发现任何关系。PQ16/fPQ16中的第5、9、11和16项预测了CAARMS中UHR的诊断结果（P值分别为0.045、0.006、0.045和0.045）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique 医学-精神病学

CiteScore

4.60

自引率

7.40%

发文量

162

审稿时长

6-12 weeks

期刊介绍： Une revue française de renommée internationale. - Un comite de rédaction représentant tous les aspects de la prise en charge psychiatrique du patient. - Une sélection rigoureuse d''articles faisant l''objet de plusieurs expertises. - Des travaux d''auteurs et de chercheurs de renommée internationale. - Des indexations dans les grandes bases de données (Current Contents, Excerpta Medica, etc.). - Un facteur d''impact qui témoigne de la grande notoriété de la revue. La tribune des publications originales de haut niveau. - Une très grande diversité des sujets traités, rigoureusement sélectionnés à travers des sommaires dynamiques : - des éditoriaux de médecins référents, - une revue de presse sur les actualités internationales, - des articles originaux pour approfondir vos connaissances, - des mises au point et des cas cliniques pour engager votre réflexion sur les indications et choix possibles au travers de mises en situation clinique, - des dossiers thématiques pour faire le tour d''une question. - L''actualité de l''AFPB : L''Encéphale publie régulièrement des comptes rendus de l''Association française de psychiatrie clinique.