Healthy mitochondrial DNA in balanced mitochondrial dynamics: A potential marker for neuro‑aging prediction (Review).

IF 2.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Biomedical reports Pub Date : 2023-08-07 eCollection Date: 2023-09-01 DOI:10.3892/br.2023.1646
Made Putra Semadhi, Dewi Mulyaty, Eli Halimah, Jutti Levita
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引用次数: 0

Abstract

The mitochondrial genome or mitochondrial DNA (mtDNA) is released as a response to cellular stress. In mitochondrial biogenesis, active communication between the mitochondria genome and nucleus is associated with the mtDNA profile that affects the mitochondrial quality. The present review aimed to assess the molecular mechanism and potential roles of mitochondria in neuro-aging, including the importance of evaluating the health status of mtDNA via mitochondrial dynamics. The normal condition of mitochondria, defined as mitochondrial dynamics, includes persistent changes in morphology due to fission and fusion events and autophagy-mitophagy in the mitochondrial quality control process. The calculated copy number of mtDNA in the mitochondria genome represents cellular health, which can be affected by a long-term imbalance between the production and accumulation of reactive oxygen species in the neuroendocrine system, which leads to an abnormal function of mitochondria and mtDNA damage. Mitochondria health is a new approach to discovering a potential indicator for the health status of the nervous system and several types of neurodegenerative disorders. Mitochondrial dynamics is a key contributor to predicting neuro-aging development, which affects the self-renewal and differentiation of neurons in cell metabolism. Neuro-aging is associated with uncontrolled mitochondrial dynamics, which generates age-associated diseases via various mechanisms and signaling routes that lead to the mtDNA damage that has been associated with neurodegeneration. Future studies on the strategic positioning of mtDNA health profile are needed to detect early neurodegenerative disorders.

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平衡线粒体动力学中的健康线粒体DNA:神经衰老预测的潜在标志物(综述)。
线粒体基因组或线粒体DNA(mtDNA)作为对细胞应激的反应而被释放。在线粒体生物发生中,线粒体基因组和细胞核之间的主动交流与影响线粒体质量的mtDNA图谱有关。本综述旨在评估线粒体在神经衰老中的分子机制和潜在作用,包括通过线粒体动力学评估线粒体DNA健康状况的重要性。线粒体的正常状态,定义为线粒体动力学,包括线粒体质量控制过程中由于分裂和融合事件以及自噬-线粒体自噬导致的形态持续变化。线粒体基因组中mtDNA的计算拷贝数代表了细胞健康,这可能会受到神经内分泌系统中活性氧产生和积累之间长期失衡的影响,从而导致线粒体功能异常和mtDNA损伤。线粒体健康是一种新的方法,可以发现神经系统和几种类型的神经退行性疾病健康状况的潜在指标。线粒体动力学是预测神经衰老发展的关键因素,神经衰老影响细胞代谢中神经元的自我更新和分化。神经衰老与不受控制的线粒体动力学有关,线粒体动力学通过各种机制和信号通路产生与年龄相关的疾病,从而导致与神经退行性变相关的mtDNA损伤。未来需要对mtDNA健康状况的战略定位进行研究,以检测早期神经退行性疾病。
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来源期刊
Biomedical reports
Biomedical reports MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
4.10
自引率
0.00%
发文量
86
期刊介绍: Biomedical Reports is a monthly, peer-reviewed journal, dedicated to publishing research across all fields of biology and medicine, including pharmacology, pathology, gene therapy, genetics, microbiology, neurosciences, infectious diseases, molecular cardiology and molecular surgery. The journal provides a home for original research, case reports and review articles.
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