The evolution of cannabinoid receptors in cancer.

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
WIREs Mechanisms of Disease Pub Date : 2023-07-01 Epub Date: 2023-02-07 DOI:10.1002/wsbm.1602
Nakea M Pennant, Cimona V Hinton
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引用次数: 4

Abstract

Cannabis sativa (cannabis) has been used as a therapeutic treatment for centuries treating various diseases and disorders. However, racial propaganda led to the criminalization of cannabis in the 1930s preventing opportunities to explore marijuana in therapeutic development. The increase in recreational use of cannabis further grew concern about abuse, and lead to further restrictions and distribution of cannabis in the 1970s when it was declared to be a Schedule I drug in the USA. In the late 1990s in some states, legislation assisted in legalizing the use of cannabis for medical purposes under physician supervision. As it has been proven that cannabinoids and their receptors play an essential role in the regulation of the physiological and biological processes in our bodies. The endocannabinoid system (ECS) is the complex that regulates the cell-signaling system consisting of endogenous cannabinoids (endocannabinoids), cannabinoid receptors, and the enzymes responsible for the synthesis and degradation of the endocannabinoids. The ECS along with phytocannabinoids and synthetic cannabinoids serves to be a beneficial therapeutic target in treating diseases as they play roles in cell homeostasis, cell motility, inflammation, pain-sensation, mood, and memory. Cannabinoids have been shown to inhibit proliferation, metastasis, and angiogenesis and even restore homeostasis in a variety of models of cancer in vitro and in vivo. Cannabis and its receptors have evolved into a therapeutic treatment for cancers. This article is categorized under: Cancer > Molecular and Cellular Physiology.
癌症大麻素受体的进化。
几个世纪以来,大麻一直被用作治疗各种疾病和病症的药物。然而,种族宣传导致20世纪30年代大麻被定罪,阻止了在治疗开发中探索大麻的机会。大麻娱乐性使用的增加进一步加剧了人们对大麻滥用的担忧,并导致大麻在20世纪70年代被宣布为美国附表一药物时受到进一步限制和分销。20世纪90年代末,一些州的立法协助在医生监督下将大麻用于医疗目的合法化。事实证明,大麻素及其受体在调节我们身体的生理和生物过程中发挥着重要作用。内源性大麻素系统(ECS)是一种调节细胞信号系统的复合物,该系统由内源性大麻肽(内源性大麻素类)、大麻素受体和负责内源性大麻毒素合成和降解的酶组成。ECS与植物大麻素和合成大麻素一起是治疗疾病的有益治疗靶点,因为它们在细胞稳态、细胞运动、炎症、痛觉、情绪和记忆中发挥作用。大麻酚类药物在体外和体内的多种癌症模型中已显示出抑制增殖、转移和血管生成,甚至恢复体内稳态。大麻及其受体已发展成为一种治疗癌症的药物。本文分类为:癌症>分子和细胞生理学。
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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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