Structural properties in ruptured mitral chordae tendineae measured by synchrotron-based X-ray phase computed tomography.

IF 2.4 3区物理与天体物理 Q2 INSTRUMENTS & INSTRUMENTATION

Journal of Synchrotron Radiation Pub Date : 2023-09-01 DOI:10.1107/S1600577523005167

Yojiro Koda, Takuro Tsukube, Masato Hoshino, Naoto Yagi, Hatsue Ishibashi-Ueda, Kenji Okada

引用次数: 0

Abstract

Tissue density measured by synchrotron-based X-ray phase computed tomography is shown to be associated with the fragility of the ruptured mitral chordae tendineae.

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基于同步加速器的x射线相位计算机断层扫描测量断裂二尖瓣腱索的结构特性。

二尖瓣复合体的结构特性与腱索断裂之间的联系尚不清楚。基于同步辐射的x射线相位计算机断层扫描(SR-XPCT)成像是一种定量分析三维形态的创新方法。本研究采用XPCT对二尖瓣返流患者的腱索进行评价，并分析二尖瓣返流患者腱索断裂的结构变化。在二尖瓣反流手术修复中获得6例二尖瓣腱索断裂，并用福尔马林固定。此外，从尸检中获得了12条健康的腱索。采用XPCT(有效像素尺寸，3.5µm;密度分辨率为1 mg cm-3)，测量每个样品中腱索的密度。随后对标本进行病理分析。破裂组平均年龄为70.2±3.0岁，对照组平均年龄为67.2±14.1岁(p = 0.4927)。所有的SR-XPCT腱索扫描均成功完成。破裂组的平均密度为1.029±0.004，对照组的平均密度为1.085±0.015 g cm-3 (p < 0.0001)。基于SR-XPCT的二尖瓣腱索破裂的密度明显低于健康的腱索。组织学检查显示断裂腱索结缔组织成分发生变化，与SR-XPCT低密度测量一致。SR-XPCT使测量二尖瓣腱索组织密度成为可能。二尖瓣腱索的低密度与破裂的二尖瓣腱索的脆性有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Synchrotron Radiation 物理-光学

CiteScore

5.10

自引率

12.00%

发文量

289

审稿时长

4-8 weeks

期刊介绍： Synchrotron radiation research is rapidly expanding with many new sources of radiation being created globally. Synchrotron radiation plays a leading role in pure science and in emerging technologies. The Journal of Synchrotron Radiation provides comprehensive coverage of the entire field of synchrotron radiation and free-electron laser research including instrumentation, theory, computing and scientific applications in areas such as biology, nanoscience and materials science. Rapid publication ensures an up-to-date information resource for scientists and engineers in the field.