Cell identity changes in ocular surface Epithelia

IF 18.6 1区 医学 Q1 OPHTHALMOLOGY
Nick Di Girolamo, Mijeong Park
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引用次数: 5

Abstract

Corneal and conjunctival epithelia arise from a common ancestral ectoderm cell, then diverge into distinct lineages. The former develops into a multilayered stratified squamous epithelium, the latter into an expansive mucous membrane that stretches the eyelid margin to the cornea's outskirts. The limbus, which intersects these epithelia, is purported to harbor corneal stem cells. Intrinsic programs that prevent these neighbouring epithelia from mixing and changing identity have not been elucidated, however microenvironmental cues that emanate following tissue damage and ensuing disease, dictate cell fate choices including those that influence form and function. Plasticity of ocular surface epithelia is gauged by their ability to undergo epithelial-mesenchymal transition, transdifferentiation, dedifferentiation and metaplastic transformation. Elucidating the molecular mechanism by which these rare and unusual phenomena arise, and persuading cells to either revert to their original state or remain newly committed, could be exploited into game-changing therapeutics for patients with corneal blindness and other diseases.

眼表上皮细胞特性改变
角膜和结膜上皮来源于共同的祖先外胚层细胞,然后分化为不同的谱系。前者发展为多层复层鳞状上皮,后者发展为扩张的粘膜,将眼睑边缘延伸至角膜边缘。角膜缘与这些上皮细胞相交,据说是角膜干细胞的宿主。阻止这些邻近上皮细胞混合和改变身份的内在程序尚未阐明,然而,在组织损伤和随后的疾病之后发出的微环境线索决定了细胞命运的选择,包括影响形态和功能的选择。眼表上皮细胞的可塑性通过其进行上皮-间质转化、转分化、去分化和化生转化的能力来衡量。阐明这些罕见和不寻常现象产生的分子机制,并说服细胞恢复到原始状态或保持新的状态,可以被用于角膜失明和其他疾病患者的游戏规则改变疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
34.10
自引率
5.10%
发文量
78
期刊介绍: Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists. The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.
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